生脉注射液对5.docVIP

生脉注射液对5 作者：陈震，王鹏，黄雯霞，刘鲁明 【关键词】 生脉注射液 ［摘要］ 目的：观察生脉注射液对5氟尿嘧啶(5fluorouracil, 5FU)抗肿瘤的增效减毒作用。方法：建立H22肝癌荷瘤鼠模型后，将50只小鼠随机分为5组：对照组、5FU组和生脉注射液（大、中、小剂量）联合 5FU组，每组10只。造模次日开始进行干预处理：对照组、5FU组和生脉注射液（大、中、小剂量）联合 5FU组分别腹腔注射等容量生理盐水、5FU、生脉注射液（大、中、小剂量）联合5FU，共14 d。停药次日处死小鼠，观察瘤重抑制率、免疫功能、肝肾功能及外周血细胞变化。结果：生脉注射液联合5FU各组小鼠的肿瘤生长抑制率明显高于5FU组和对照组（P＜0.05)；与对照组相比，5FU组CD3、CD4、CD4/CD8、IgG、IgM值明显降低（P＜0.05)，而各生脉注射液联合5FU组CD3、CD4、CD4/CD8、IgG、IgM值升高（P＜0.05)；与对照组相比，5FU组的血丙氨酸氨基转移酶升高、白细胞和血小板数量降低（P＜0.05)；而各生脉注射液联合5FU组血丙氨酸氨基转移酶与对照组比较无明显变化，白细胞数下降程度较轻。结论：生脉注射液可增加5FU的抑瘤效果，提高机体免疫功能，减轻化疗毒副反应。 　　［关键词］ 抑瘤率; 免疫力; 副反应; 5氟尿嘧啶; 生脉注射液 　　Experimental study on effects of Shengmai Injection: enhancing 5FU antitumor efficacy and reducing its toxicity 　　ABSTRACT Objevtive: To observe the effects of Shengmai Injection on enhancing efficacy and reducing toxicity of 5fluorouracil (5FU). Methods: Fifty hepatoma 22 bearing mice were randomly divided into five groups: control group, 5Fu group, Shengmai Injection (low, medium and high dose) combined with 5FU groups. There were 10 mice in each group. Mice in the five groups were injected introperitoneally the same amount of normal saline, 5FU (20 mg#12539;kg－1#12539;d－1) and Shengmai Injection (3.5 ml#12539;kg－1#12539;d－1, 7 ml#12539;kg－1#12539;d－1 and 14 ml#12539;kg－1#12539;d－1) combined with 5FU respectively, once a day for 14 days. After that, all mice were killed and the tumor inhibiting rates, index of immunological function, liver and kidney function and the blood cells in the peripheral blood were observed. Results: The tumor inhibiting rates were higher in each Shengmai Injection combined with 5FU group than that in the 5FU group (P＜0.05). The levels of CD3、CD4、CD4/CD8、IgG、IgM in 5FU group were lower (P＜0.05), while those in the three Shengmai Injection combined with 5FU groups were higher than those in the control group (P＜0.05). The level of serum alanine aminotransferase (ALT) was higher and the WBC and PLT counts in the peri