肿瘤干细胞表面标记物CD44在胃癌组织中的表达及意义.docVIP

肿瘤干细胞表面标记物CD44在胃癌组织中的表达及意义 张 泽，曾祥勇，段 珊(海南省农垦总医院普通外科，海南省海口市 570100) 引用本文：张泽，曾祥勇，段珊. 肿瘤干细胞表面标记物CD44在胃癌组织中的表达及意义[J].中国组织工程研究，2016，20(45): 6760-6765. DOI: 10.3969/j.issn.2095-4344.2016.45.011 ORCID: 0000-0003-1465-776X(张泽) 文章快速阅读： 文题释义： CD44蛋白Expression of tumor stem cell surface marker CD44 in gastric cancer tissues and its significance Zhang Ze, Zeng Xiang-yong, Duan Shan (Department of General Surgery, Hainan Provincial Nongken General Hospital, Haikou 570100, Hainan Province, China) Abstract BACKGROUND: Studies have shown that CD44 expression is closely associated with malignant transformation of gastric cancer. OBJECTIVE: To study the expression of CD44 in gastric cancer tissues and its clinical significance. METHODS: Gastric cancer specimens from 94 cases of gastric cancer after surgery and normal gastric tissue specimens from 30 cases undergoing gastroscope examination were collected and detected using S-P method. The positive expression rate of CD44 protein in these two groups was compared, and the relationship between CD44 and prognosis was analyzed. RESULTS AND CONCLUSION: The positive expression rate of CD44 protein in the gastric cancer group (73%) was significantly higher than that in the normal group (3%) (P 0.05). The positive expression rate of CD44 protein in gastric cancer patients was remarkably associated with TNM stage, differentiation degree, invasion depth and lymph node metastasis (P 0.05). The 3-year survival rate of gastric cancer patients positive for CD44 protein was significantly lower than that of negative patients (P 0.05). The higher TNM staging indicated the lower differentiation degree, and lymph node metastasis and CD44 positive expression were independent risk factors (P 0.05). To conclude, the expression of CD44 protein is related to the clinical pathological features and prognosis of gastric cancer patients to some extents. Subject headings: Stomach Neoplasms; Neoplastic Stem Cells; Antige