处方和粒径减少提高难溶于水的抗疟疾药物的生物利用度浅析.docVIP

Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity Hongxing Wang, Qigui Li, Sean Reyes, Jing Zhang, Lisa Xie, VictorMelendez, Mark Hickman, andMichael P. Kozar Decoquinate癸氧喹酯 (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water. In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation（固体分散体的方法是：DQ为处方，使其可以在水相中分散溶解）. Among many polymers and surfactants tested, polyvinyl