第五六章多组分反应和串联反析.pptVIP

第五章 Multi-Component Reactions Organic Synthesis Organic Synthesis Multicomponents reactions (MCRs) are those reactions in which three or more reactants come together in a single reaction vessel to form a new product which contains portions of all the components MCR A+B+C…. P Convergency Complexity Productivity Selectivity Atom economy Diversity 一、多组分反应的历史 Ivar Karl Ugi (1930-2005), the inventor of the most significant isocyanide based MCRs. 二、多组分反应涉及的反应机理 1.离子机理 异腈参与的多组分反应大多为离子机理。 Angew. Chem. Int. Ed. 1998, 37, 2234 2.自由基机理 Angew. Chem. Int. Ed. 2003, 42, 3490 3.周环反应机理 Tetrahedron Lett. 1998,