TriActive主要功效成分简介.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Histologic studies have characterized the progression of atherosclerotic lesion types. The earliest lesions (from the first decade on) are characterized histologically by isolated foam cells or fatty streaks in the vessel wall. Lesion growth at this stage occurs mainly by lipid accumulation. Intermediate lesions, which may be associated with small extracellular lipid pools, progress to atheroma, which has a core of extracellular lipid. These lesions may be seen starting in the third decade. Starting in the fourth decade, lesions may progress to the fibrous plaque stage, which is characterized by accelerated increases in smooth muscle and collagen. Complicated lesions are characterized by thrombosis, fissure, and hematoma formation.2 Atherosclerosis Timeline 2 Stary HC, Chander AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. Circulation. 1995;92:1355–1374. Slide 2 * * * * * * * * * * * * * * * * * * * * * * * * * * * * In 2000, the USFDA announced a qualified health claim for dietary supplements containing EPA and DHA Omega-3 fatty acids and the reduced risk of Coronary Heart Disease (CHD). Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. * * * * * * * * * * * * * * * * * 心血管病的危险因子 可调整因子 吸烟 超重/肥胖 身体运动少 饮食不良 糖尿病/代谢综合症 高胆固醇血症 高血压 高半胱胺酸血症 高C反应蛋白水平 不能调整因子 年龄 性别 种族 遗传(家庭食) * * 胆固醇与心血管疾病 胆固醇经自由基氧化激发血管内皮细胞损伤、炎症 过多低密度胆固醇引发血微小团块形成 高密度胆固醇协助清楚体内多余的脂肪和胆固醇 总胆固醇水平升高、低密度胆固醇水平升高和低/高密度胆固醇比例升高，都属心血管疾病的警号 * * 循环血中单核细胞 血管内腔 血管内皮细胞 血管内低密度胆固醇 血细胞 媒介氧化 被氧化的低密度胆固醇 空泡细胞 空泡细胞 坏死因子E 血管内皮细胞下空隙 血管平滑肌 单核细胞转化为巨噬细胞 内皮细胞损伤 内皮细胞功能失调 * * 心血管健康--功效营养素補充 * * Benefits of EPA/DHA 抗炎症 (Anti-inflammatory), 抗血栓 (Anti-thrombotic), 抗心律不整 (Anti-arrhythmic), 降脂血作用 (Hypolipidemic), 舒张血管 (Vasodilatory) Source: Am J Clin Nutr. 1999;70:560S-569S