Implication of DNA Demethylation and Bivalent Hist【DOC精选】.docVIP

Implication of DNA Demethylation and Bivalent Histone Modification for Selective Gene Regulation in Mouse Primordial Germ Cells Kentaro Mochizuki,1 Makoto Tachibana,2 Mitinori Saitou,3,4 Yuko Tokitake,1 and Yasuhisa Matsui1,* Introduction Germ cells are the only cells capable of giving rise to truly totipotent cells, via differentiation to sperms/eggs and subsequent fertilization. In mouse embryos at around embryonic day (E) 7.25, a small population of primordial germ cells (PGCs) in the extraembryonic mesoderm and derived from the epiblasts is first “fate-determined”. Shortly before PGC fate