SPLIT-FACE模式评价肌底液产品对抗衰老护肤品的增效作用.docVIP

SPLIT-FACE模式评价肌底液产品对抗衰老护肤品的增效作用 　　[摘要]目的：采用split-face模式评价肌底液产品对抗衰老护肤品boosting效应的临床效果和安全性。方法：对20名北京地区健康女性受试者进行使用前后自身对照的临床研究，让受试者分左、右脸使用肌底液+/-抗衰老面霜（联合侧与面霜侧）4周，分别在0周、2周、4周检测面部皮肤角质层含水量、皮肤光泽度、皮肤弹力、眼部细纹以及角质细胞脱落数量。结果：与0周（联合侧54.58±8.43，面霜侧53.92±10.3）相比，皮肤角质层含水量在4周（联合侧65.68±9.61，面霜侧59.66±7.25）有明显的升高，组间比较4周差异有显著性(P＜0.05)。皮肤光泽度在4周（联合侧9.41±1.73，面霜侧9.24±1.53）与0周（联合侧8.09±1.56，面霜侧7.97±1.67）相比有明显的升高，2周、4周组间比较差异无显著性（P＞0.05）。皮肤弹性从2周（联合侧0.74±0.08，面霜侧0.71±0.07）开始提高，4周（联合侧0.78±0.08，面霜侧0.73±0.05）提高更为明显，4周组间差异有显著性（P＜0.05）。眼部细纹各参数在2周、4周与0周相比有明显改善，但各参数组间差异均无统计学意义（P＞0.05）。皮肤角质细胞剥脱数量在4周（联合侧45.36±5.67，面霜侧47.65±5.08）比0周（联合侧48.53±5.53，面霜侧48.94±3.93）有明显改善，且4周组间差异有统计学意义（P＜0.05）。研究过程中无不良反应发生。结论：同时使用肌底液产品和抗衰老面霜比单独使用抗衰老面霜具有更好的效果，对于干性皮肤人群来说，有改善皮肤眼部细纹和皮肤弹性，提高皮肤光泽度，角质层含水量和皮肤角质层完整性的作用，且具有较高安全性。 　　[关键词]Boosting效应；肌底液产品；split-face模型；抗衰老护肤品 　　[中图分类号]R322.99 [文献标识码]A [文章编号]1008-6455（2014）08-0640-04 　　 　　Boosting effect of booster product when co-applying with anti-aging cosmetic 　　GAO Ya-qian1, KIM Eunjoo2, SUN Nan3, WU Yan3, YEON Jaeho1, AN Susun1 　　[1. Amore-pacific (Shanghai) R I Center, Shanghai 201801, China；2. Amore-pacific R D Center, Yongin-si 446-729, Korea ；3. Peking University First Hospital, Beijing 100034, China] 　　 　　Abstract：Objective To evaluate the boosting effect of booster product when co-applying with anti-aging cosmetic via split-face mode. Methods A self-controlled clinical study was performed in 20 healthy female volunteers,which involved a four-week split-face treatment with booster product +/- anti-aging cosmetic (combined group cream only group).Skin hydration, skin elasticity, skin gloss, eye fine wrinkles and skin scaling (corneocytes) were measured at week 0, week 2 and week 4.Results After four-week application, positive improvements of all reference parameters were observed. Skin hydration, skin elasticity, skin gloss and skin scaling (corneocytes) were demonstrated with group significance (P＜0.05) at week 4. No adverse effect was observed.Conclusion Co-applying