二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕的效果分析.docVIP

二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕的效果分析 　　doi：10.3969/j.issn.1007-614x.2014.21.48 　　摘 要 目的：分析应用二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕的临床疗效。方法：2011年10月-2013年10月收治多囊卵巢综合征合并不孕患者126例，按数字表法随机分为研究组和对照组，每组63例；对照组给予克罗米芬单药治疗，研究组给予二甲双胍联合克罗米芬治疗，比较两组性激素水平、血糖指标及排卵和妊娠治疗情况。结果：研究组FSH、T、FINS水平均优于对照组，且排卵率69.84%及妊娠率23.80%均高于对照组的26.98%、11.11%，组间比较均具有统计学意义（P0.05）。结论：二甲双胍联合克罗米芬治疗对多囊卵巢综合征合并不孕患者临床疗效具有积极影响。 　　关键词 多囊卵巢综合征 不孕 二甲双胍 克罗米芬 　　Effect analysis of metformin combined with clomiphene in the treatment of polycystic ovarian syndrome combined with infertility 　　Wang Yangai 　　The Central Hospital of Yuzhou City，Henan 461670 　　Abstract Objective：To analyze the clinical effect of metformin combined with clomiphene in the treatment of polycystic ovarian syndrome combined with infertility.Methods：126 cases of polycystic ovarian syndrome patients with infertility were selected from October 2011 to October 2013.In accordance with the digital table method，the patients were randomly divided into the study group and the control group with 63 cases in each.The control group were given clomiphene treatment alone.The study group were treated with metformin combined with clomiphene.The sex hormone levels，glycemic index，ovulation and pregnancy treatment situation of patients in two groups were compared.Results：The FSH、T、FINS levels of the study group were superior to the control group.The ovulation rate of 69.84% and pregnancy rate of 23.80% were higher than 26.98%，11.11% of the control group.The comparison among groups were statistically significant（P0.05）.Conclusion：The clinical effect of metformin combined with clomiphene in the treatment of polycystic ovarian syndrome combined with infertility has a positive impact. 　　Key words Polycystic ovarian syndrome；Infertility；Metformin；Clomiphene 　　多囊卵巢综合征临床主要表现为月经稀发、多毛、肥胖等，是导致女性不孕的主要因素之一，目前药物治疗是常用治疗方案[1]。本文将126例多囊卵巢综合征合并不孕确诊患者为研究对象，分析二甲双胍联合克罗米芬治疗的临床疗效，现报告如下。 　　资料与方法 　　2011年10月-2013年10月收治多囊卵巢综合征合并不孕患者126例，按数字表法随机分为研究组和对照组，每组63例；研究组年龄22～35岁，平均（29.56±1.12）岁；对照组年龄25～37岁，平