动态检测hs―CRP在急性胰腺炎病情评估中的临床价值.docVIP

动态检测hs―CRP在急性胰腺炎病情评估中的临床价值 　　doi：10.3969/j.issn.1007-614x.2014.14.60 　　摘 要 目的：探讨hs-CRP在急性胰腺炎病情发展过程中的变化。方法：2010年6月-2013年6月收治急性胰腺炎患者81例，分为MAP患者26例（Ⅰa组），SAP患者55例（Ⅰb组）。选取同期在本院行健康体检的健康人75例设为对照组（Ⅱ组），检测各组第1天、第3天、第7天、第10天和第14天的hs-CRP水平。结果：急性胰腺炎患者血清hs-CRP浓度在第1天、第3天、第7天、第10天均明显高于对照组，差异均有统计学意义（P0.05）；SAP患者各个时间段的hs-CRP浓度均明显高于MAP患者，差异有统计学意义（P0.01）。结论：动态检测hs-CRP浓度可以对急性胰腺炎的病情程度进行评估和判断。 　　关键词 hs-CRP 急性胰腺炎 临床价值 　　The clinical values of the detection of high-sensitivity C-Reaction Protein in the condition judgment of acute pancreatitis 　　Song Lixin1，Chen Juanjuan1，Zhang Xiaojian2 　　Peoples Hospital of Feicheng city in Shandong Province，2716001 　　Taian Central Hospital of Shandong Province，2710002 　　Abstract Objective：To investigate the change of hs-CRP in the development of the patients with acute pancreatitis.Methods：We selected 81 cases of patients with acute pancreatitis from June 2010 to June 2013.These patients were divided into 26 cases of MAP（Ⅰa group）and 55 cases of SAP（Ⅰb group）.75 healthy people who undertook physical examination at the same period were set as the control group.The level of hs-CRP were detection on the 1st，3rd，7th，10thday.Results：On the 1st，3rd，7th，10thday，the level of hs-CRP of acute pancreatitis patients were higher than the control group，and the difference was significant（P0.05）.The level of hs-CRP of severe acute pancreatitis patients were higher than the mild acute pancreatitis at all the time，and the difference was actively significant（P0.01）.Conclusion：The detection of high-sensitivity C-Reaction Protein could evaluate the condition judgment of the acute pancreatitis. 　　Key words hs-CRP；Acute pancreatitis；Clinical value 　　急性胰腺炎（Acute pancreatitis，AP）是临床上常见的急腹症，是因为各种原因导致胰腺分泌的消化酶自我消化胰腺及其周围组织而引起的疾病[1]，其临床特点为上腹痛、腹胀、恶心、呕吐、血淀粉酶及尿淀粉酶升高等。AP可分为重症急性胰腺炎（severe acute pancreatitis，SAP）和轻症急性胰腺炎（mild acute pancreatitis，MAP）。AP起病急、发展快，其引起的级联放大炎性反应非常凶险，因此早期、准确地评估AP的危险程度，对于AP的临床治疗和处理有重要的指导意义。本研究对81例AP患者的hs-CRP进行动态检测，现报告如下。 　　资料与方法 　　2010年6月-2013年6月收治急性