右美托咪定在胸外科手术患者中的应用.docVIP

右美托咪定在胸外科手术患者中的应用 　　【摘要】目的实践性研究右美托咪定运用于胸外科手术患者的安全性以及有效性。方法右美托咪定给药方法为, 在患者麻醉诱导之前、在诱导时与诱导后(8±1.7)min之内输注1 μg/kg。细致的观察两组麻醉效果、麻醉维持期丙泊酚TCI的靶饱和度以及麻醉恢复室里用药情况与副作用等。结果通过分析发现右美组在麻醉维持阶段丙泊酚TCI的靶饱和度每毫升少于(2.37±0.4) μg的病例数显著的超过非右美组, 差异有统计学意义(P0.01)。麻醉恢复室里右美组予以曲马多的病例数显著少于非右美组。右美组在诱导时以及诱导后用药一过性血压提升率少于麻醉诱导前用药, 差异有统计学意义(P0.01)。右美组心动过缓的出现率少于(4.1±0.3)%。结论予以右美托咪定的有效性在于能够减少麻醉维持阶段丙泊酚TCI的靶饱和度, 减少苏醒阶段其他药物的使用率。 　　【关键词】右美托咪定；胸外科手术；应用 　　 　　Application of dexmedetomidine in thoracic surgery CUI Hong-xian, PAN Na, SHUAI Xun-jun, et al. Qingdao Municipal Hospital, Qingdao 266011, China 　　【Abstract】#8195;Objective#8195;To study safety and effectiveness of dexmedetomidine in thoracic surgery. Methods#8195;Dexmedetomidine administration methods was that before induction of anesthesia, at the time of induction and post induction (8±1.7) minutes giving patients infusion of 1 μg/kg, carefully observed anesthesia effect of two groups, propofol TCI saturation in anesthesia maintenance phase and the recovery room medication and side effects of anesthesia. Results#8195;Propofol TCI saturation in anesthesia maintenance phase of dexmedetomidine group was less than (2.37 ± 0.4)μg/ml, which was significantly more than nondexmedetomidine group, P0.01. Anesthesia recovery room dexmedetomidine group to display case of tramadol with less than nondexmedetomidine group. Dextromethorphan group in the induction and inducing drugs after a blood pressure increase rate less than before the induction of anesthesia medication, P0.01. Dextromethorphan group heartbeat bradycardia occurrence rate of less than (4.1±0.3)%. Conclusion#8195;Dexmedetomidine can reduce the propofol TCI saturation in anesthesia maintenance phase and use rate of other drugs in recovery stage. 　　【Key words】Dexmedetomidine; Thoracic surgery; Application此次将随机抽取自2011年4月~2012年2月来本院胸外科进行手术的200例患者, 并分析100例患者胸外科手术中右美托咪定的使用效果, 同时和没有使用右美托咪定的病例进行对比, 实践性研究右美托咪定在胸外科手术患者中的安全性以及有效性, 相关内容如下所述。 　　1资料与方法 　　1. 1一般资料随机抽取自2011年4月~2012年2月来本院胸外科进行手术的200例患者, 其中10