喜炎平联合西咪替丁治疗儿童手足口病疗效分析.docVIP

喜炎平联合西咪替丁治疗儿童手足口病疗效分析 　　doi：10.3969/j.issn.1007-614x.2014.14.51 　　摘 要 目的：探讨喜炎平联合西咪替丁治疗儿童手足口病的临床疗效。方法：2013年1月-2014年1月收治手足口病患儿120例，随机分成观察组和对照组，各60例。对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg?日）5%GS静滴；观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg?日）静滴，两组治疗5天。结果：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较差异有统计学意义（P0.05）。观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），有效22例（36.7%），无效10例，总有效率83.3%，两组比较差异有统计学意义（P0.05）。结论：喜炎平联合西咪替丁治疗儿童手足口病症状缓解快，疗效显著，值得推广。 　　关键词 喜炎平 西咪替丁 利巴韦林 手足口病 　　Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease 　　Qin Yanling，Kou Jianjun 　　Pediatrics of The second peoples Hospital of Anding District of Dingxi City in Gansu Province，743000 　　Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg?day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg?day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total ef