奥美拉唑与生长抑素合用治疗食管静脉曲张破裂出血的临床有效性与安全性综合评价.docVIP

奥美拉唑与生长抑素合用治疗食管静脉曲张破裂出血的临床有效性与安全性综合评价 　　doi：10.3969/j.issn.1007-614x.2014.14.14 　　摘 要 目的：研究奥美拉唑与生长抑素联合治疗食管静脉曲张破裂出血的临床有效性与安全性。方法：将进行治疗的142例食管静脉曲张破裂出血患者随机分为试验组和对照组，试验组给予奥美拉唑与生长抑素进行联合治疗，对照组仅给予生长抑素治疗，比较两组患者的治疗效果。结果：试验组71例患者中，显效38例（53.5%），有效25例（35.2%），无效8例（11.2%）；对照组71例患者中，显效23例（32.3%），有效31例（43.6%），无效17例（23.9%），试验组的治疗效果优于对照组（P0.05）。结论：生长抑素联合奥美拉唑在治疗食管静脉曲张破裂出血中能够显著控制出血症状，提高用药安全性，值得临床推广应用。 　　关键词 生长抑素 奥美拉唑 疗效评价 　　Comprehensive evaluation of the clinical efficacy and safety of omeprazole combined with somatostatin in the treatment of esophagus varicosity burst hemorrhage 　　Zhang Linshan，Yang Yanchun，Hu Jun ，Yang Changhua，Wan Jingjun 　　The internal medicine of the peoples hospital in Sansui County，Qiandongnan State，Guizhou Province，556500 　　Abstract Objective：To study the clinical efficacy and safety of omeprazole combined with somatostatin in the treatment of esophagus varicosity burst hemorrhage.Methods：142 cases of patients with esophagus varicosity burst hemorrhage for treatment were randomly divided into the experimental group and the control group.The experimental group were given omeprazole combined with somatostatin treatment，while the control group were only given somatostatin treatment.Compare the treatment effect of patients between two groups.Results：In the 71 cases of patients in the experimental group，markedly effective was 38 cases（53.5%），effective was 25 cases（35.2%），invalid was 8 cases（11.2%）.In the 71 cases of patients in the control group，markedly effective was 23 cases（32.3%），effective was 31 cases（43.6%），invalid was 17 cases（23.9%）.The treatment effect of the experimental group was better than that of the control group（P0.05）.Conclusion：Somatostatin combined with omeprazole in the treatment of esophagus varicosity burst hemorrhage can significantly control the bleeding symptoms，enhance the medication security，so it is worthy of clinical application. 　　Key words Somatostatin；Omeprazole；Therapeutic evaluation 　　肝硬化门脉高压极其容易导致食管静脉曲张破裂出血，该病发病隐匿且突然，