妊娠合并甲状腺功能减退症激素替代治疗后的妊娠结局分析.docVIP

妊娠合并甲状腺功能减退症激素替代治疗后的妊娠结局分析 　　[摘要] 目的 分析妊娠合并临床甲状腺功能减退及亚临床甲状腺功能减退经激素替代治疗后妊娠结局。 方法 回顾分析2012年1月～2013年12月广东省深圳市南山区妇幼保健院产科92例临床甲状腺功能减退（OH组）及98例亚临床甲状腺功能减退妊娠妇女（SCHO组），所有患者均给予左旋甲状腺素（L-T4）治疗，选择同期甲状腺功能正常的妊娠妇女300例作对照组，对三组进行妊娠结局分析比较。 结果 OH组孕妇胎膜早破的发生率（27.2%）高于对照组（17.0%），差异有统计学意义（P 0.05）。 结论 临床甲状腺功能减退和亚临床甲状腺功能减退孕妇经规范激素（L-T4）替代治疗不良妊娠结局发生情况与正常孕妇相似。 　　[关键词] 妊娠；妊娠期甲状腺功能减退症；妊娠结局；左旋甲状腺素 　　[中图分类号] R581.2 [文献标识码] B [文章编号] 1673-7210（2014）08（b）-0140-05 　　Analysis of pregnancy outcome on Hormone replacement therapy of hypothyroidism during pregnancy 　　XU Yue1 CHEN Qiaobin2 HUANGFU Ying1 ZHANG Jing2 　　1.Department of Obstetrics， Nanshan District Maternal and Child Health Care of Shenzhen City， Guangdong Province， Shenzhen 518052， China； 2.Department of Laboratory， Nanshan District Maternal and Child Health Care of Shenzhen City， Guangdong Province， Shenzhen 518052， China 　　[Abstract] Objective To explore the pregnancy outcome on Hormone replacement therapy of clinical hypothyroidism and subclinical hypothyroidism during pregnancy. Methods 92 pregnancy women with clinical hypothyroidism （OH group） and 98 pregnancy women with subclinical hypothyroidism during pregnancy （SCHO group） from January 2012 to December 2013 in Department of Obstetrics of Nanshan District Maternal and Child Health Care of Shenzhen City were retrospectively analyzed， all these patients were given the treatment of sodiumlevothyroxine （L-T4）， and 300 normal pregnancy women in the same period were selected as control group. The outcome of pregnancy in three groups were analyzed. Results The incidence of premature rupture of membrane in OH group （27.2%） was higher than that in the control group （17.0%）， the difference of two groups was statistically significant （P 0.05）. Conclusion The L-T4 replacement therapy of hypothyroidism during pregnancy can improve the adverse outcome of pregnancy. 　　[Key words] Pregnancy； Hypothyroidism； Regnancy outcomes； L-T4 　　甲状腺是脊柱动物非常重要的内分泌器官，位于哺乳动物颈部甲状腺软骨下方，气管两旁。人类的甲状腺形似蝴蝶，犹如遁甲