QFeverCoxiella burnetii WeeblyQ热贝氏柯克斯体 Weebly.pptVIP

* * Vaccines :- prepared from formalin killed whole cells attenuated strains trichloroacetic acid extracts Prophylaxis:- Pasteurization and sterilization of milk and other dairy products Disinfect utensils, machines used in farm areas for birthing Regular testing of animals and those who work closely with them Protective Personal Equipment BARTONELLA INTRODUCTION Family Bartonellaceae contain two genera Bartonella Grahamella Grahamella does not infect humans Bartonella contain 3 species: B.bacilliformis  B.quintana B.henselae BARTONELLA BACILLEFORMIS Carrions disease Causes OROYA fever MORPHOLOGY: Gram negative Pleomorphic strict aerobe motile, small bacillu0.3-0.5x0.2-0.5mc found inside erytrocyte infected persons Opt. temp 25-28 c CULTURE; Grow in semisolid nutrient agar with 10% rabbit serum 0.5%Hb Growth is slow takes about 10 days PATHOGENISIS:- Causes OROYA fever Transmitted by SAND flies INCUBATION PERIOD; 3 weeks to 3 months CLINICAL FEATURES:- Fever Headache Chills Severe anemia Several weeks after recovery pt. develop nodular lesions on the body Secondarily infect produce ulcers – VERUGA PERUANA Lab diagnosis:- Demonstrated in blood smear by GIEMSA stain Seen in cytoplasm and adhere to cell surface Grown on NA agar contain rabbit serum, Hb Guinea pig inoculation leads to VERUGA PERUANA TRETMENT:- Susceptible to penicillin