PROGRESS IN RENAL CELL CARCINOMA Wikispaces在肾细胞癌的进展Wikispaces.pptVIP

Debi Foli - Bio 316 Biology of Cancer Renal tumors Dr. Abdelaty Shawky Dr. Gehan Mohamed Learning objectives 1. List the classification of renal tumors. 2. Describe renal oncocytoma. 3. Describe renal cortical adenoma. 4. Discuss risk factors for renal cell carcinoma. 5. Discuss clinical presentation of RCC. 6. list the different histologic subtypes of RCC. 7. understand the TNM staging, grading of RCC. 8. Recognize the pathological features of Wilms tumor. * Classification of Renal tumors: I. Benign tumors: Cortical adenoma. Oncocytoma. II. Malignant tumors: Renal cell carcinoma. Wilms tumor. Both benign and malignant tumors occur in the kidney. With the exception of oncocytoma, the benign tumors rarely cause clinical problems. Malignant tumors, on the other hand, are of great importance clinically and deserve considerable emphasis. By far the most common of these malignant tumors is renal cell carcinoma, followed by Wilms tumor, which is found in children Renal cortical adenoma * Clinical Features: Usually an incidental finding. Often seen in patients receiving long-term hemodialysis, also more common in kidneys scarred from chronic pyelonephritis. * Gross Pathology: The tumors are smaller than 5 mm. Soft, well-circumscribed mass with yellow to gray cut surface surrounded by compressed adjacent kidney parenchyma On microscopic examination: They are composed of complex, branching, papillomatous structures. The cells may also grow as tubules, glands, cords, and sheets of cells. The cells are cuboidal to polygonal in shape and have regular, small central nuclei, scanty cytoplasm, and no atypia. Renal adenoma Renal oncocytoma * Clinical Features: Most are asymptomatic, although flank pain may be a presenting complaint; hematuria may be seen. Computed tomography or magnetic resonance imaging may identify central scar. * Gross Pathology: Well-circumscribed, homogeneous cortical tumor Mahogany-brown cut surface. Often shows a central, irregular fibro