Revised estimates of human cochlear tuning from otoacoustic经修订的估计人类耳蜗调谐从耳声.pptVIP

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Revised estimates of human cochlear tuning from otoacoustic经修订的估计人类耳蜗调谐从耳声.ppt

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Revised estimates of human cochlear tuning from otoacoustic经修订的估计人类耳蜗调谐从耳声

Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements Christopher A. Shera, John J. Guinan, Jr., and Andrew J. Oxenham Background Key characteristic of hearing: frequency tuning of cochlear filters Sensory cells respond to a preferred range of energy Filter bandwidth ? 1/ sharpness of tuning Background Assessments of cochlear tuning Non-human mammals ANF recordings in live anesthetized animals Humans Psychophysical measures Masking procedures Pure tone detection in background noise Downfalls Assumptions underlying pure tone detection method are uncertain Physcophysical detection tasks depend on filter characteristics as well as neural processing No way to validate behavioral measures in humans Aims Compare current measures of human cochlear tuning with animal measures Develop a noninvasive measure of cochlear tuning based on otoacoustic emissions Test correspondence between physiological and behavioral measures of frequency selectivity Aims Compare current measures of human cochlear tuning with animal measures Develop a noninvasive measure of cochlear tuning based on otoacoustic emissions Test correspondence between physiological and behavioral measures of frequency selectivity Determination of bandwidth QERB Measure of “sharpness” of tuning based on critical bandwidth QERB(CF) = CF/ERB(CF) Smaller bandwidth = higher QERB Results Aims Compare current measures of human cochlear tuning with animal measures Develop a noninvasive measure of cochlear tuning based on otoacoustic emissions Test correspondence between physiological and behavioral measures of frequency selectivity Experiment II Subjects Guinea pigs (n=9) Cats (n=7) Humans (n=9) Measure stimulus-frequency otoacoustic emissions (SFOAEs) Cochlear traveling waves scattered by the mechanical properties of the cochlea Recordable sounds emitted from the ear Evoked by a pure tone Calculate SFOAE group delays (NSFOAE) Negative of slope of emission-phase vs frequency