Thymosin alpha 1 Microbiologia TorVergata胸腺肽α1 microbiologia Tor Vergata.pptVIP

Thymosin α1 BIOLOGICAL PROPERTIES OF THYMOSIN α1 In vitro Actions Increase in production of interleukin-2, interferon a, interferon g, and interleukin-7 in activated lymphocytes. Enhanced expression of high-affinity interleukin –2 receptors. Decreases terminal deoxynucleotidyl transferase (TdT) activity in bone arrow precursors and splenic lymphocytes. Induction of expression of phenotypic T-cell markers. Enhancement of natural killer recruitment and lytic activity. Antagonizement of steroid-induced apoptosis in immature thymocytes. Increases MHC Class 1 expression of lymphoid non-lymphoid cells. Increases expression of CD3+4+T-Cells from CD34+ stem cells. Tα1 decreases replication of SENDAI virus in MDCK Thymosin has all the requirements to be defined a smart molecule, exerting different action according to the different environment. Medicine some time forgets that the complex network resident inside our body drives the effects of some drugs. In this view we can distinguish between “stupid” and “intelligent” drugs. Intelligent drugs act as regulatory agents in relationship with the signals coming from inside. To this category belongs thymosin-?1 and other biological molecules. Zadaxin is the compound which was responsible for reconstitution of immune function when thymic tissue was given back to thymectomized animals. It is a 28 amino acid peptide, with no tertiary structure and no other post-translational modifications except an N-terminal acetylation. Zadaxin is the N-terminus of a larger peptide, Pro-thymosin. Although the mechanism of cleavage is unknown, like many other peptides, it circulates at about 1 ng/ml. Slide 4 To evaluate whether the increased survival of the mice was associated with the decrease of the viral titer in the lung, mice were infected, treated with different treatments schedule and sacrificed 6 days after infection. This table shows that combination therapy with Amantidine,a/b Interferon and Ta1 of mice caused a 98%