FK506结合蛋白51在脑胶质瘤组织中的表达及其临床意义.docVIP

FK506结合蛋白51在脑胶质瘤组织中的表达及其临床意义 　　[摘要] 目的 探讨FK506结合蛋白51（FKBP51）在脑胶质细胞瘤组织中的表达及其临床意义。 方法 选取本院2013年1月～2015年1月的223例脑胶质瘤患者作为研究对象，选取同期来自于颅脑损伤手术患者的23例正常脑组织进行对照研究。采用免疫组织化学法检测FKBP51的表达水平，分析其表达水平与脑胶质瘤病理组织类型和病理分级的关系。 结果 脑胶质瘤的FKBP51阳性率显著高于正常脑组织，差异有统计学意义（P0.05）。不同病理类型脑胶质瘤组织的FKBP51阳性率比较，差异有统计学意义（P0.05）。恶性的胶质母细胞瘤FKBP51的表达水平显著高于良性的星形细胞瘤，差异有统计学意义（P0.05）。FKBP51的表达水平与脑胶质瘤分级呈正相关（r=0.30，P0.05）。 结论 FKBP51表达与脑胶质瘤的病理类型和临床病理分级具有相关性，有可能作为脑胶质瘤标志物用于临床病理特征分析和预后判断。 　　[关键词] FK506结合蛋白51；表达；脑胶质瘤；病理分级 　　[中图分类号] R739.41 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0012-03 　　[Abstract] Objective To explore the expression and clinical significance of FK506 binding protein 51 （FKBP51） in brain glioma tissue. Methods 223 cases of brain glioma from January 2013 to January 2015 in our hospital were selected as the research group，23 cases of normal brain tissues from patients with brain injury was selected as the control group.The expression level of FKBP51 was tested by using immunohistochemical method，and the relationship between its expression level and gliomas histopathologic types and pathology grade was analyzed. Results The positive rate of FKBP51 in glioma tissue was higher than that in normal brain tissue，with significant difference （P0.05）.There were significant difference in the positive rate of FKBP51 in different pathological types of brain glioma tissues （P0.05）.The expression level of FKBP51 in malignant glioblastomas was higher than that in benign astrocytoma，with significant difference （P0.05）.The expression level of FKBP51 had positive relationship with pathology grade （r=0.30，P0.05）. Conclusion The expression of FKBP51 is related to histopathologic types and pathology grade of glioma，it may be as glioma markers for analysis clinicopathologic feature and judgement prognosis. 　　[Key words] FK506 binding protein 51；Expression；Brain glioma；Pathology grade脑胶质瘤是发病率、病死率最高的中枢神经系统原发性肿瘤，恶性程度高，生存率低。不同病理组织类型和分级与脑胶质瘤的预后密切相关，如星形细胞瘤的生存期为5～10年，间变性星形细胞瘤的生存期为2～3年，胶质母细胞瘤的生存期仅为12～15个月，但相同病理类型的脑胶质瘤预后也有较大差异，目前尚