四君子汤加减对复发性尖锐湿疣患者血清IL―2、IL―4水平的影响与疗效观察.docVIP

四君子汤加减对复发性尖锐湿疣患者血清IL―2、IL―4水平的影响与疗效观察 　　【摘要】目的： 通过观察四君子汤加减对复发性尖锐湿疣患者血清白细胞介素4（IL-4）和白细胞介素2（IL-2）的影响，探讨四君子汤加减治疗复发性尖锐湿疣的机理。方法： 将 80例复发性尖锐湿疣患者经除疣治疗后随机分为治疗组与对照组，治疗组给予中药治疗。检测两组患者治疗前后血清 IL-4、IL-2的水平，同时观察两组治疗后疣体的复发情况。结果： 治疗组治疗后血清IL-4水平较治疗前降低，且低于治疗后对照组水平，差异均具有统计学意义（P0.05）。治疗组治疗后血清 IL-2 水平较治疗前升高，且明显高于治疗后对照组的水平，差异均具有统计学意义（P0.05）。治疗后治疗组复发率为 17.14 %，明显低于对照组，差异具有统计学意义（P0.05）。结论： 四君子汤加减能调节机体的细胞免疫功能，可有效防治尖锐湿疣的复发。 　　【关键词】 四君子汤加减；复发性尖锐湿疣；IL-2；IL-4 　　【Abstract】Objectives： To investigate the therapeutic mechanism of Si-jun-zi Decoction in treating recurrent condyloma acuminatum by observing the effect of Si-jun-zi Decoction on Interleukin 4 （IL-4） and Interleukin 2 （IL-2） in the patients with recurrent condyloma acuminatum. Methods： Seventy patients with recurrent condyloma acuminatum were allocated randomly to Si-jun-zi Decoction group or control group after surgical removal of warts， and the treatment groups received treatment of Si-jun-zi Decoction. The IL-4 and IL-2 of the patients were measured before and after treatments. Meanwhile， the recurrence of warts was observed and compared after treatment. Results： The level of IL-4 in Si-jun-zi Decoction group decreased significantly after treatment， and was significantly lower than that of placebo group （P 0.05）. The level of serum IL-2 in Si-jun-zi Decoction group remarkably increased after treatment， and was significantly higher than that of control group （P 0.05）. Si-jun-zi Decoction treatment group had a lower recurrence rate （17.14 %） than control group （P 0.05）. Conclusion： Si-jun-zi Decoction possesses the ability of regulating the cellular immune function and effectively preventing the recurrence of condyloma acuminatum. 　　【Key words】Si-jun-zi Decoction； Recurrent condyloma acuminatum； Interleukin 4 （IL-4）； Interleukin 2 （IL-2） 　　【中图分类号】R752.5+3【文献标志码】A 　　尖锐湿疣（condyloma acuminatum，CA）是由人类乳头瘤病毒（HPV）感染所致，中医将尖锐湿疣称为“臊疣”和“臊瘊”。近年研究表明人类细胞免疫失衡是临床上决定尖锐湿疣转归的主要因素，因此调节机体免疫，减少复发率是临床治疗的主要方向之一。中医药治疗尖锐湿疣临床取得较好疗效，笔者通过四君子汤加减治疗复发性尖锐湿疣取得