妊娠期高血压疾病凝血指标及血脂变化的临床研究.docVIP

妊娠期高血压疾病凝血指标及血脂变化的临床研究 　　[摘要] 目的 探讨妊娠期高血压疾病患者凝血指标及血脂变化的临床价值。 方法 选取2013年1～12月本院住院分娩患者。随机抽选病案号末尾是6的正常妊娠妇女60例作为对照组，命名为A组；选择妊娠期高血压疾病患者77例为研究组，依据病情轻重再分亚组，其中将35例诊断符合妊娠期高血压但未达到子痫前期的患者，为B组；将 42例诊断符合子痫前期及子痫的患者，为C组。比较三组凝血酶原时间、活化的部分凝血酶原时间、纤维蛋白原、血小板计数、平均血小板体积、血小板分布宽度、血清总胆固醇（total cholesterol，TC）、甘油三酯、高密度脂蛋白、低密度脂蛋白共10项指标。 结果 三组血脂及凝血指标均符合单因素方差分析，差异有统计学意义（P0.05），其中：FIB、PDW、PT与TG对妊娠期高血压患者及其严重程度呈平行关系，差异有统计学意义（P0.05）。结论 血脂及凝血指标变化对于妊娠期高血压疾病的诊断和防治具有重要临床价值。 　　[关键词] 妊娠期高血压；凝血酶原时间；纤维蛋白原；血小板；血清总胆固醇；甘油三酯 　　[中图分类号] R714.246 [文献标识码] A [文章编号] 1673-9701（2016）07-0016-03 　　[Abstract] Objective To investigate the clinical value of coagulation indicator and plasma lipid changes of the patients with hypertensive disorder complicating pregnancy. Methods Pregnant patients who were admitted into our hospital from January to December 2013 were selected. 60 normal pregnant women whose medical case number was ended with 6 were randomly collected as control group and named group A. 77 hypertensive disorder complicating pregnant women were selected as study group and divided into subgroup by the severity of the condition. 35 patients who were diagnosed as hypertensive disorder but not met the criteria of preeclampsia were named as group B and 42 patients who were diagnosed as preeclampsia and eclampsia were named as group C. A total of 10 indicators including prothrombin time （PT）， activated partial thromboplastin time （APTT）， fibrinogen （FIB）， platelet count （PLT）， mean platelet volume （MPV）， platelet distribution width （PDW）， cholesterol total （TC）， triglyceride （TG）， high density lipoprotein （HDL） and low density lipoprotein （LDL） of the three groups were compared. Results Plasma lipids and coagulation indicators of the three groups were all in accord with one-way analysis of variance with significant differences （P0.05）. The level of FIB， PDW， PT and TG had a parallel relationship with the severity of hypertensive disorder complicating pregnancy， which had statistical significance（P0.05）. Conclu