新诊断2型糖尿病与既往诊断的2型糖尿病糖化血红蛋白和炎症水平的比较.docVIP

新诊断2型糖尿病与既往诊断的2型糖尿病糖化血红蛋白和炎症水平的比较 　　【摘要】 目的：比较新诊断2型糖尿病（T2DM）与既往诊断的T2DM炎症因子等实验室指标的异同。方法：选取2014年1月-2015年1月本院收治的T2DM患者600例作为研究对象，按病程分为新诊断T2DM组289例和既往诊断T2DM组311例。取患者空腹静脉血，应用糖化血红蛋白分析仪采用高效液相色谱法（HPLC）检测糖化血红蛋白（HbA1c），应用全自动生化分析仪采用葡萄糖氧化酶检测血糖，采用ELISA法检测血清肿瘤坏死因子（TNF-α）、白介素-1（IL-1）和白介素-6（IL-6）等炎症因子水平。结果：新诊断T2DM组血清TNF-α、IL-1和IL-6水平均明显高于既往诊断T2DM组，比较差异均有统计学意义（P0.05）。结论：新诊断T2DM患者血清炎症水平明显高于既往诊断的T2DM患者，可能与既往诊断T2DM患者能较好的控制血糖平稳有关。 　　【关键词】 2型糖尿病； 炎症因子； 糖化血红蛋白 　　【Abstract】 Objective：To compare the similarities and differences between the laboratory indexes of newly diagnosed type 2 diabetes mellitus（T2DM） and the previously diagnosed T2DM inflammatory factors.Method：From January 2014 to January 2015，600 patients with T2DM admitted to our hospital were selected as the research objects，they were divided into 289 patients with the newly diagnosed T2DM group and 311 patient with the previously diagnosed T2DM group according to the course of disease.The fasting venous blood were extracted，glycosylated hemoglobin analyzer was used for the detection of glycosylated hemoglobin（HbA1c） by using the method of high performance liquid chromatography，blood glucose was detected by full automatic biochemical analyzer using glucose oxidase，the serum tumor necrosis factor（TNF-α），interleukin-1（IL-1），interleukin-6（IL-6） and other inflammatory cytokines were detectes by ELISA.Result：The levels of TNF-α，IL-1 and IL-6 in the newly diagnosed T2DM group were higher than the previously diagnosed T2DM group，the differences were statistically significant（P0.05）.Conclusion：The serum levels of inflammation in newly diagnosed T2DM patients were significantly higher than those of T2DM patients with previously diagnosed T2DM，which may be related to the better control of blood glucose level. 　　【Key words】 Type 2 diabetes mellitus； Inflammatory factor； Glycosylated hemoglobin 　　糖尿病在全世界呈爆发趋势，其中2型糖尿病（T2DM）占糖尿病的90%～95%。2010年流行病学调查显示我国成年人糖尿病患病率达11.6%，糖尿病前期人群占成年人50.1%[1]。糖尿病慢性并发症包括周围血管病变、肾脏病变、视网膜病变和周围神经病变，是导致T2DM患者截肢和终