激素联合环磷酰胺治疗间质性肺疾病及对患者血清白介―6水平的影响.docVIP

激素联合环磷酰胺治疗间质性肺疾病及对患者血清白介―6水平的影响 　　[摘要] 目的 探讨激素联合环磷酰胺治疗间质性肺疾病对患者血清白介-6水平的影响。方法 选取该院2014年3月―2015年7月间收治的120例间质性肺疾病患者随机分组，观察组60例给予激素联合环磷酰胺治疗，对照组60例单纯给予激素治疗，比较两组患者治疗前后FEV1、FVC、FVC（%）、DLCO、DLCO（%）、HRCT评分、IL-6水平。结果 两组患者治疗前FEV1、FVC、FVC（%）、DLCO、DLCO（%）、HRCT评分、IL-6水平比较差异无统计学意义（P0.05）；观察组治疗后FEV1、FVC、FVC（%）、DLCO、DLCO（%）、HRCT评分、IL-6水平与对照组比较差异有统计学意义（P0.05）。 结论 激素联合环磷酰胺治疗间质性肺疾病效果显著，能降低患者血清白介-6水平，缓解患者临床症状。 　　[关键词] 激素；环磷酰胺；间质性肺疾病；血清白介-6 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）04（c）-0050-02 　　[Abstract] Objective To discuss the hormone combined with cyclophosphamide in treatment of interstitial lung disease and its effect on serum interleukin -6 in patients. Methods 120 cases of patients with interstitial lung disease treated in our hospital from March 2014 to July 2015 were randomly divided into two groups with 60 cases in each， the observation group were treated with hormone combined with cyclophosphamide， the control group were treated with simple hormone， and the FEV1， FVC， FVC （%）， DLCO， DLCO （%）， HRCT scores and IL-6 levels before and after treatment were compared between the two groups. Results There was no obvious difference in the FEV1， FVC， FVC（%）， DLCO， DLCO（%）， HRCT score and IL-6 level between the two groups before treatment（P0.05）， there were obvious differences in the FEV1， FVC， FVC（%）， DLCO， DLCO（%）， HRCT score and IL-6 level between the two groups after treatment（P0.05）. Conclusion The effect of hormone combined with cyclophosphamide in treatment of interstitial lung disease is obvious， which can reduce the serum interleukin-6 level and relieve the clinical symptoms of patients. 　　[Key words] Hormone； Cyclophosphamide； Interstitial lung disease； Serum interleukin -6 　　间质性肺疾病主要表现为弥漫性肺实质、肺间质炎症及肺泡炎症。主要病变部位为肺间质，肺泡周围组织也常被累及[1]。其除损害肺间质外，对肺实质组织、肺毛细支气管等也有一定损害。此病病程长，患者患病后肺泡毛细血管功能逐渐丧失，最终发展为蜂窝肺及弥漫性肺纤维化，致使患者呼吸衰竭，最终致死[2]。研究表明，间质性肺疾病患者血清白介-6水平明显高于正常者，临床证实血清白介-6可促使肺纤维化[3]。该研究对该院2014年3月―2015年7月收治的60例间质性肺疾病患者采取激素联合环磷酰胺治疗，并观察血清白介-6水平变化，报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选取