甲氨蝶呤在异位妊娠保守性手术中的作用.docVIP

甲氨蝶呤在异位妊娠保守性手术中的作用 　　【摘要】 目的：探究甲氨蝶呤（MTX）在异位妊娠保守性手术中的作用。方法：选择2013年2月-2014年9月笔者所在医院收治的异位妊娠患者360例，将患者随机分为对照组与观察组，各180例。对照组采用单纯性腹腔镜保守手术，观察组在对照组基础上联合局部注射MTX，观察对比两组患者术后血β-hCG值变化情况、治愈成功率、药物不良反应及1年内宫内妊娠率。结果：观察组治愈率为97.8%，明显高于对照组的89.4%（P0.05）；两组患者术后1、4、12 d血β-hCG值均明显低于术前24 h，且观察组比对照组下降更为明显（P0.05）；观察组1年内宫内妊娠率为66.1%，明显高于对照组的47.2%（P0.05）；两组患者均无严重不良反应。结论：异位妊娠保守性手术治疗中应用MTX，安全有效，临床疗效显著，值得临床广泛应用。 　　【关键词】 甲氨蝶呤； 异位妊娠； 保守性手术 　　中图分类号 R714.22 文献标识码 B 文章编号 1674-6805（2016）9-0011-02 　　【Abstract】 Objective：To explore the effect of Methotrexate pregnancy conservative surgery in ectopic.Method：360 cases of ectopic pregnancy in our hospital from February 2013 to September 2014 were selected，they were randomly divided into the control group and the observation group，180 cases in each group.The control group was treated with laparoscopic conservative surgery，the observation group based on the control group combined with local injection of MTX，the postoperative serum β-hCG value changes，cure success rate，adverse drug reactions and within 1 year the intrauterine pregnancy rate of the two groups were observed and compared.Result：The cure rate of the observation group was 97.8%，which was significantly higher than 89.4% in the control group（P0.05）.1，4，12 d serum β-hCG value of the two groups were all significantly lower than the preoperative 24 h，and the observation group than in the control group decreased more significantly（P0.05）.Within 1 year of the observation group the rate of intrauterine pregnancy was 66.1%，which was significantly higher than 47.2% in the control group（P0.05）.The patients of two groups had no serious adverse reactions.Conclusion：Conservative surgical treatment of ectopic pregnancy MTX，safe and effective，clinical curative effect is remarkable，it is worthy of clinical application. 　　【Key words】 Methotrexate； Ectopic pregnancy； Conservative surgery 　　First-author’s address：The People’s Hospital of Hechi，Hechi 547000，China 　　doi：10.14033/j.cnki.cfmr.2016.9.006 　　异位妊娠是妇