疏风止嗽方治疗咳嗽变异性哮喘临床研究.docVIP

疏风止嗽方治疗咳嗽变异性哮喘临床研究 　　摘要：目的 评价疏风止嗽方治疗咳嗽变异性哮喘（CVA）的临床疗效。方法 将120例CVA患者随机分为中药组、西药组、中西组各40例。中药组口服疏风止嗽方，西药组吸入沙美特罗替卡松粉吸入剂（舒利迭），中西组予疏风止嗽方+舒利迭，疗程均为28 d。观察3组治疗前后中医证候积分、咳嗽自测量表评分、嗜酸性粒细胞（EOS）计数、IgE计数、肺功能指标。结果 中药组、西药组、中西组愈显率分别为45.00%、20.00%、85.00%，总有效率分别为97.50%、77.50%、95.00%，组间比较差异有统计学意义（P0.05）。3组治疗后比较肺功能指标均明显改善（P0.05）。3组支气管激发试验转阴率比较差异无统计学意义（P0.05）。结论 疏风止嗽方治疗CVA具有良好的临床疗效，其作用机制可能是抗变态反应炎症、降低气道反应性。 　　关键词：疏风止嗽方；咳嗽变异性哮喘；临床研究 　　DOI：10.3969/j.issn.1005-5304.2016.12.008 　　中图分类号：R259.622.5 文献标识码：A 文章编号：1005-5304（2016）12-0030-04 　　Clinical Study on Cough Variant Asthma Treated with Shufeng Zhisou Formula LU Shi-xiu1， LI Bu-man1， YIN Li-hu1， XIANG Ping-chao1， ZHANG Er-ming1， WANG Xue-jing2， QU Yu-min3， ZHENG Yu-qin4， LIU Pei-hong1， PANG Lei1 （1. Peking University Shougang Hospital， Beijing 100144， China； 2. China-Japan Friendship Hospital， Beijing 100029， China； 3. Xuanwu TCM Hospital， Beijing 100050， China； 4. Shijingshan Hospital， Beijing 100043， China） 　　Abstract： Objective To evaluate the clinical efficacy of Shufeng Zhisou Formula in treating cough variant asthma （CVA）. Methods Totally 120 CVA patients were randomly divided into TCM group， WM group and integrated TCM and WM group， with 40 cases in each group. TCM group was treated with Shufeng Zhisou Formula； WM group was treated with Seretide； integrated TCM and WM group was treated with Shufeng Zhisou Formula and Seretide. One course of treatment was twenty-eight days for each guoup. TCM syndrome scores， self testing cough scores， EOS numbers， IgE concentration and lung function before and after treatment in the three groups were compared. Results The markedly effective rate was 45.00% in the TCM group， 20.00% in the WM group and 85.00% in the integrated TCM and WM group. The total effective rate of TCM group was 97.50% in the TCM group， 77.50% in the WM group and 95.00% in the integrated TCM and WM group， with statistical significance （P0.05）. The lung function of the three groups significantly improved （P0.05）. The differ