祛萎健胃汤治疗慢性萎缩性胃炎伴癌前病变120例临床分析.docVIP

祛萎健胃汤治疗慢性萎缩性胃炎伴癌前病变120例临床分析 　　[摘要] 目的 祛萎健胃汤治疗慢性萎缩性胃炎伴癌前病变的疗效。方法 随机收集120例于2011年5月―2015年5月在福州市中医院脾胃病专科门诊治疗的患者，随机分为治疗组与对照组，每组60例，对照组予摩罗丹进行治疗；治疗组口服祛萎健胃汤进行治疗。两组患者临床疗效、中医症状轻重分级、以及胃黏膜病理积分差异进行对比。 结果 治疗组总有效率90.0%优于对照组71.7%（P0.01）；治疗组经治疗后胃黏膜萎缩积分为（2.5±1.3）分，肠上皮化生积分为（1.5±0.7）分，异型增生积分为（1.3±0.7）分，差异有统计学意义（P0.05）。结论 祛萎健胃汤治疗CAG伴癌前病变能明显改善临床症状，逆转胃黏膜病理改变。 　　[关键词] 慢性萎缩性胃炎；癌前病变；祛萎健胃汤 　　[中图分类号] R246.1 [文献标识码] A [文章编号] 1674-0742（2016）10（b）-0185-03 　　[Abstract] Objective To analyze the curative effects of chronic atrophic gastritis with precancerous lesions treated with Quweijianwei Decoction. Methods Random collected 120 cases had in May 2011 to May 2015 in Fuzhou City Hospital of traditional Chinese medicine spleen stomach specialist outpatient treatment of patients randomly divided into treatment group and control group， 60 cases in each group， patients in control group were treated with Rama Dan treatment； treatment group were treated with removing wilt Jianwei Decoction treatment. The clinical efficacy of the two groups of patients， TCM symptoms and grade， as well as gastric mucosal pathological score differences were compared. Results The treatment group the total efficiency was 90% better than the control group 71.7%（P 0.01）； treatment group after treatment of gastric mucosa atrophy score was （2.5±1.3）points， intestinal epithelium of students score （1.5 ± 0.7）points， dysplasia points to（1.3± 0.7）points were significantly lower than the control group（P 0.05）. Conclusion The implementation of Quweijianwei Decoction for CAG with precancerous lesions can significantly improve the clinical symptoms， reverse the pathological changes of gastric mucosa. 　　[Key words] Chronic atrophic gastritis； Precancerous lesion； Quweijianwei Decoction 　　慢性萎缩性胃炎（chronic gastritis，CAG），主要是由胃黏膜固有腺体萎缩而造成黏膜变薄，或者是伴有Dys（异型增生）和IM（肠上皮化生）等病理特点而引起的一种常见病[1-5]。为了减少胃癌的发生和逆转胃癌前病变或阻断病变的进展，笔者采用祛萎和胃汤治疗120例2011年5月―2015年5月的福州市中医院脾胃病专科门诊慢性萎缩性胃炎患者，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　随机收集120例曾于福州市中医院脾胃病专科门诊患者，以随机数学表法将