血清降钙素原、C反应蛋白在儿童感染性疾病中的诊断价值.docVIP

血清降钙素原、C反应蛋白在儿童感染性疾病中的诊断价值 　　【摘要】 目的：探讨血清降钙素原和C反应蛋白在儿童感染性疾病早期诊治中的应用价值。方法：选取2012年6月-2014年8月本科收治的1268例感染性疾病患儿为研究对象，根据病原学与血清学结果分为两组，比较两组入院治疗前及治疗后PCT、CRP、WBC及ESR水平。结果：治疗前细菌感染组PCT、CRP水平及阳性率均显著高于非细菌感染组，细菌感染组PCT阳性率明显高于CRP阳性率，以上比较差异均有统计学意义（P0.05）。结论：PCT和CRP在儿童感染性疾病中均显著增高，但是在早期判定感染性质上PCT较CRP更优越，PCT能够更准确地反映感染性疾病的程度，对感染性疾病的诊断以及预后判断具有良好的临床应用价值。 　　【关键词】 降钙素原； C反应蛋白； 儿童； 感染 　　【Abstract】 Objective： To investigate the application value of procalcitonin（PCT） and C-reactive protein（CRP） in the early diagnosis and treatment about the disease of infection in children. Method： 1268 children with infection in the pediatrics of our hospital from June 2012 to August 2014 were selected as the research objects.They were divided into two groups according to the results of pathogen and serum.The levels of PCT，CRP，WBC and ESR in the two groups were compared before and after treatment. Result： Before treatment the levels and positive rates of PCT and CRP in the bacterial infection group were significantly higher than those in the non-bacterial infection group，in the bacterial infection group，the positive rate of PCT was higher than the positive rate of CRP，the differences above were all statistically significant（P0.05）. Conclusion： The levels of PCT and CRP increase significantly in children with infection， but PCT was superior to CRP in the early diagnosis of bacterial infection. The serum procalcitonin can accurately reflect the degree of infectious diseases， it has a good clinical application value in the diagnosis and prognosis of infectious diseases. 　　【Key words】 Procalcitonin； C-reactive protein； Children； Infection 　　First-author’s address： Ningde Hospital Affiliated to Fujian Medical University， Ningde 352100， China 　　doi：10.3969/j.issn.1674-4985.2015.28.003 　　感染性疾病是儿科重要的疾病，病原菌包括病毒、细菌、非典型病原、寄生虫及真菌，其中最常见的是细菌及病毒[1]。脓毒症是由多种致病原感染后引起的全身炎症反应，严重者尤其是细菌感染者可发生多器官功能障碍综合征（MODS）和多器官功能衰竭（MOF），是儿科危重患儿死亡的主要原因之一[2]。因此，及早正确判断感染的性质，以早期及时使用抗菌药物能明显降低死亡率，对临床治疗意义重大。但由于儿科危重症患儿很少表现出特异的症状和体征，故临床诊断主要依靠