血清降钙素原和前清蛋白测定在小儿感染性疾病中的临床应用研究.docVIP

血清降钙素原和前清蛋白测定在小儿感染性疾病中的临床应用研究 　　【摘要】 目的：探讨血清降钙素原（PCT）和前清蛋白（PA）的测定在小儿感染性疾病中的临床诊断价值。方法：随机选取本院儿科经病理学确诊的50例患儿（包括细菌感染组26例，病毒感染组24例）。选取同期性别、年龄相匹配的健康儿25例作为健康对照组。对比三组患儿血清PCT和PA的水平。结果：细菌感染组血清PCT水平最高，病毒感染组次之，健康对照组最低（F=5.123 91，P0.05）；病毒感染组PCT和PA联合检测的阳性率为45.83%。结论：血清PCT和PA检测仅能作为诊断小儿细菌感染性疾病的可靠指标，两者联合检测能提高诊断小儿细菌感染性疾病的敏感性。 　　【关键词】 血清降钙素原； 前清蛋白； 小儿感染性疾病； 诊断 　　【Abstract】 Objective：To explore the clinical value of serum procalcitonin （PCT） and prealbumin （PA） detection in pediatric infectious diseases.Method：The 50 children who were diagnosed by pathology in our hospital were randomly selected.50 cases were divided into 26 cases of bacterial infection group and 24 cases of virus infection group.25 healthy children were selected as healthy control group with matching age and sex at the same period.The serum PCT and PA levels were compared among the three groups.Result：The PCT level of the bacterial infection group was highest，then was the viral infection group，and the healthy control group was the lowest，the difference was statistically significant（F=5.123 91，P0.05）.The positive rate of combined detection of PCT and PA in viral infection group was 45.83%.Conclusion：PCT and PA detection can only to be a reliable diagnosis indicator of the pediatric bacterial infection.Combined detection of PCT and PA can improve the sensitivity of diagnosis of bacterial infectious diseases in children. 　　【Key words】 Serum procalcitonin； Prealbumin； Pediatric infectious diseases； Diagnosis 　　First-author’s address：The First People’s Hospital of Huizhou City，Huizhou 516003，China 　　doi：10.3969/j.issn.1674-4985.2016.20.017 　　小儿感染性疾病是临床上常见的儿科疾病，常见的有细菌感染性疾病和病毒感染性疾病，其中，细菌感染性疾病是极为常见的一种[1-2]。由于小儿感染性疾病的病原学诊断需耗费大量的时间，导致临床上抗菌药物的盲目使用，加速耐药菌株的形成和发展，加大了临床治疗该病的难度。故寻找便捷、高效的确诊小儿感染性疾病的实验指标具有非常重要的临床应用价值[3-4]。国内学者研究表明，血清降钙素原（PCT）和前清蛋白（PA）可用于诊断和鉴别小儿感染性疾病，亦可用于监测小儿感染的病情，反映炎症活动的情况，较传统的小儿感染性疾病检测指标具有更高的敏感性和特异性[5-6]。故本研究通过监测本院儿科经病理学确诊50例患儿和同期性别、年龄相匹配的健康儿25例的PCT和PA水平，旨在从临床观察PCT和PA水平的变化，为临床诊断小儿感染性疾病提供科学的研究依据。现报道如下。 　　1