DNA疫苗在家禽中的应用.pdf

of of ofAnimaland the Branch,ChineseAssociation Biolo$ical Veterinary Proceedinss10山Symposium Sc——i—e————n—c—e 183一186． [10]hAgren，Bjorn novel CTAl一DD aB Lowenadler，Nilslycke．Aconceptinmucosaladjuvanticity：Theadjuvantiscell—targetedfusionproteinthatin· the activecholeratoxinA1 andCell 1． corporatescnzymatically subunit．ImmunologyBiology．1998：1440—171 [11]MartinM，MichalekSM，KatzJ．Roleofinnateimmunefactorsinthe of A．Infect adjuvantactivitymonophosphoryllipid —507． [12]张小飞，杨倩．粘膜免疫佐剂的研究进展．免疫学杂志，2004；20(3)：62—65． DNAisa enhancerof andmucosalimmune Bsurface withintranasal [13]McCluskieMJ，DavisHL．CpG potent systemic responsesagainsthepatitis antigen administrationtomiec．JImmunol，1998；161(9)：4463—6． AbstractMucosalimmuneisthefirstlineofdefense invaders．Mucosaland system againstforeign systemicresponse caD_beinducedattenuated the tractoften thevac- vaccine．However，the by digestivejuicethroughalimentary degrades theamountofthe hastobeincreasedinclinical orderto mucosal cine，SO antigen practice．Inimproveorganism immunity and immune the kindsofmucosalimmune havebeenstudied．Thearti— system responseagainst antigen，different adjuvant cle adetailsummarizationonthe about recentstudiesmucosalimmune gives adjuvant． wordsmucosalimmune Key system；adjuvant；CpG；MPL DNA疫苗在家禽中的应用