亮氨酸钙在小鼠体内吸收效果的研究.pdfVIP

亮氨酸钙在小鼠体内吸收效果的研究 翁连进 （华侨大学化工与制药工程系，福建泉州 362021 ） 摘要：目的：观察L-亮氨酸钙对小鼠股骨生长的影响。方法：将KM 系小鼠随机分成4 组，分别喂养 L-亮氨酸钙、复方氨基酸钙和普通饲料，通过测量相应饲料喂养小鼠的体重，血清中钙、磷、碱性磷酸 酶含量以及股骨长度、重量、密度和股骨中羟脯氨酸、钙含量等指标，观察亮氨酸钙对 KM 系小鼠股 骨生长的影响。结果：L-亮氨酸钙对小鼠体重，血清中磷，股骨中羟脯氨酸含量以及股骨长度没有显著 性影响（*P0.05 ），而小鼠血清中钙、碱性磷酸酶，股骨重量以及股骨密度和钙含量显著高于普通饲料 组小鼠（*P0.05 ），相同含钙元素剂量条件下，L-亮氨酸钙与复方氨基酸钙对小鼠股骨生长没有显著性 差异。结论：L-亮氨酸钙具有明显的补钙效果，能促进小鼠股骨生长。 关键词：亮氨酸钙； 复方氨基酸钙；吸收 中图分类号： 文献标识码： 文章编号： Absorption effects of L-leucine calcium in rats WENG Lianjin ( Department of Chemical industry and pharmacy engineering , Fujian quanzhou 362021) Abstract: Objective: To study the effects of leucine calcium on the growth of thighbone in rat. Methods: KM rat were equally divided into 4 groups and fed with feedstuffs containing L-leucine calcium compound at different dosage ，compound calcium amino acid chelate and common feed. In order to study the effect on thighbone by leucine calcium in KM rat, the weight of rat, the concentration of calcium, phosphorous, AKP in blood, the length, weight, density, calcium content and hydroxyproline content of the rat thighbone were measured in every group. Results: The weight of rat, phosphorous in blood, hydroxyproline content in bone and bone length have no significantly influence (*P0.05), the concentration of calcium and AKP in blood, the weight, density and calcium content of rat thighbone were significantly increased compare the leucine calcium group to common feed group （*P0.05）, at the same calcium element dosage, growth of thighbone between leucine calcium compound and compound calcium amino acid chelate have no significantly influence. Conclusio