The origin of the neoplastic stromal cell in giant cell tumor of bone1.pdfVIP

The Origin of the Neoplastic Stromal Cell in Giant Cell Tumor of Bone MANUELA WU¨ LLING, PHD, GUENTER DELLING, MD, AND EDELGARD KAISER, PHD Fibroblastlike stromal cells, which are always present as a component of giant cell tumor of bone (GCT), can be observed in both in vivo and cultured cell samples. Although they are assumed to trigger the cancer process in GCT, the histogenesis of GCT stromal cells is poorly understood. It is known that mesenchymal stem cells (MSCs) can develop to osteoblasts. Evidence has been presented that GCT stromal cells can also develop to osteoblasts. A connection