血清胱抑素C、尿酸与缺血性脑血管病颈动脉粥样硬化的关系.docVIP

血清胱抑素C、尿酸与缺血性脑血管病颈动脉粥样硬化的关系 　　摘要：目的 探?血清胱抑素C、尿酸与缺血性脑血管病患者颈动脉粥样硬化的关系。方法 选择缺血性脑血管病患者250例，应用彩色多普勒超声检查患者颈动脉内-中膜厚度（IMT），综合评估患者颈动脉粥样硬化程度及斑块性质。选择同期250名年龄和性别相匹配的健康体检者作为对照组，观察两组之间胱抑素C、尿酸的差异。运用逻辑回归分析方法分析血清胱抑素C、尿酸对缺血性脑血管病患者颈动脉粥样硬化的作用。结果 ①病例组血清胱抑素C值[1.00（0.21）μmol/L]显著高于对照组[0.92（0.17）μmol/L]，病例组尿酸值[300（85.25）μmol/L]显著高于对照组[286（94.25）μmol/L]，差异均有统计学意义（均P0.05）。③多元逻辑回归分析显示，胱抑素C水平升高是颈动脉粥样斑块形成的独立危险因素（OR=1.052，95%CI：1.029-1.075）。结论 ①血清胱抑素C、尿酸水平升高是发生缺血性脑血管病的重要危险因素；②血清胱抑素C升高与缺血性脑血管病患者颈动脉粥样硬化的形成及发展密切相关，检测血清胱抑素C水平可以反映其颈动脉粥样硬化程度。 　　关键词：缺血性脑血管病；颈动脉粥样硬化；血清胱抑素C；尿酸 　　The Relationship between Serum Cystatin C， Uric Acid and Carotid Atherosclerosis in Ischemic Cerebrovascular Disease 　　FEI Lin，WANG Yong-hong 　　（Department of Internal Medicine-Neurology，First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China） 　　Abstract：Objective To investigate the relationship betweenserumcystatin C （Cys-C） ，uric acid （UA） level andcarotid atheroscleroticin patientswith ischemic cerebrovascular disease（ICVD）. Methods A total of 250 patients with first-ever ischemic stroke.Color Doppler ultrasound of carotid artery wasused to detect the carotid artery intima-mediathickness （IMT）.The degree of CAS in patients was assessed comprehensively.selecting 250 age and sex-matched healthy controls as control group.The Cys-C，UA concentrations indexes were measuredby an enzymatic method and carefully analyzed.Therelationship betweenthe serum Cys-C，UA level and the carotid atherosclerotic plaques were analyzed. Results ①The levels of Cys-C，UA in patients with ischemic cerebrovascular disease was higher than thatof the controlsubjects（P0.05）.②Wefound that the serum Cys-Clevelsinboth IMT thickening and the plaque formation groupswere significantly higher than the normal IMT group（P0.05）.And UA levels of the plaque formation group were significantly higher than the normalIMT group（P0.05）.③Multivariate logistic regression analysisshowed that the increasedCys-C level was an independent risk facto