非小细胞肺癌高钙血症多学科综合治疗近期疗效观察.docVIP

非小细胞肺癌高钙血症多学科综合治疗近期疗效观察 　　摘要：目的 探?以化疗为基础，联合放射性核素及双磷酸盐的综合治疗手段治疗肺癌骨转移性高钙血症的近期临床疗效。方法 采用非小细胞肺癌含铂化疗方案联合放射性核素89SrCL2及唑来膦酸治疗33例肺癌骨转移所导致的高钙血症，动态观察患者血钙浓度变化。结果 33例患者高钙血症有效缓解23例，总有效缓解率为69.7%；化疗有效组12例，高钙血症有效缓解11例，缓解率为91.7%，化疗无效组21例，高钙血症有效缓解12例，缓解率为57.1%，化疗有效组高钙血症的有效缓解率高于化疗无效组，差异有统计学意义（χ2=4.309，P=0.042）。化疗有效组及无效组高钙血症有效缓解的平均持续时间分别为（82.2±12.4）d及（68.5±7.6）d，差异有统计学意义（t=3.007，P=0.011）。结论 化疗联合放射性核素及双磷酸盐的综合治疗手段可以有效缓解部分非小细胞肺癌骨转移性高钙血症，其中化疗有效患者接受该治疗手段显示出更好的疗效。 　　关键词：关键词 非小细胞肺癌；恶性高钙血症；综合治疗 　　中图分类号：R730.53 文献标识码：A 　　Hort-term Efficacy Observation of Multidisciplinary Synthetic Therapy of Non-small-cell Lung Cancer 　　with Hypercalcemia 　　WANG Qiong1， DENG Yong-Jun2， SHI Yun-Fei3， LIU Huang-Peng2， LI Jue2 　　（1. Department of Pharmacy， The Peoples Hospital of Luoping County， Luoping 655800，Yunnan，China；2. Department of Thoracic Surgery， The Fourth Affiliated Hospital of Kunming Medical University， Kunming 650017， Yunnan，China；3. Department of Thoracic Surgery，The First Affiliated Hospital of Kunming Medical University，Kunming 6500327， Yunnan，China） 　　Abstract：Objective To explore the short-term clinical effects of multidisciplinary synthetic therapy of chemotherapy combined with radionuclide and bisphosphonates in treatment on 33 non-small-cell lung cancer patients with hypercalcemia. Methods 33 non-small-cell lung cancer patients with hypercalcemia were treated with platinum-based chemotherapy combined with radionuclide 89SrCL2 and zoledronic acid by the support of Granulocyte-macrophage colony-stimulating factor （GM-CSF）. The level of blood-calcium was observed regularly and the efficacy was evaluated. Results Hypercalcemia in 23 cases were found to be alleviated effectively and the alleviation rate was 69.7%， thereinto， 11 cases happened in 12 chemotherapy-effective patients （chemotherapy-effective group） and the other 12 cases occurred in 21 chemotherapy-ineffective patients （chemotherapy-ineffective group）. The effective alleviation rate of hypercalcemia in chemotherapy-effec