基于数据挖掘方法研究挥发油透皮促渗作用与中药药性间的关.docx

基于数据挖掘方法研究挥发油透皮促渗作用与中药药性间的关联性杨文国1, 2，陈 军1,3*，刘 培1，蒋秋冬1,3，王 研3，周 成3，段金廒1**1. 南京中医药大学 江苏省中药资源产业化过程协同创新中心，江苏 南京 2100232. 南京中医药大学 信息技术学院，江苏 南京 2100233. 南京中医药大学 药学院药物制剂研究室，江苏 南京 210023摘要：分析文献报道的中药挥发油的促渗作用与来源中药药性的相关性。通过文献调研，收集了34种具有透皮促渗作用报道的中药挥发油，采用频数分析法、变量交叉表法进行直观分析和关联分析，并通过变量压缩法建立一般线性模型分析来源中药药性（四气、五味、归经）与透皮促渗效果的关系。结果表明：具有透皮促渗效果的挥发油均来自辛味药材，阳性药性有利于中药挥发油透皮促渗；五味对于渗透效果影响不大（P值=0.6982），而四气和归经对于渗透效果影响很显著（P值=0.011和0.077），四气的影响尤其大。提示中药挥发油透皮促渗作用与来源中药药性有明显的相关性和规律性。关键词：中药药性，透皮促渗，中药挥发油，数据挖掘，一般线性模型Study on association between penetration enhancement effect of essential oils and drug properties of Chinese herbal medicines by data mining methodYANG Wen-guo1,2, CHEN Jun1,3*, LIU Pei1, JIANG Qiu-dong1,3, WANG Yan3, ZHOU Cheng3, DUAN Jin-ao1**1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Information Technology College, Nanjing University of Chinese Medicine, Nanjing 210023, China;3. Pharmaceutical Research Laboratory, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.Abstract: To study the association between penetration enhancement effect of essential oils and drug properties of Chinese herbal mdicine. By literature research, 34 kinds of essential oils possessing penetration enhancement effects were collected. The methods of frequency analysis and variable crosstab were used for intuitive analysis and association analysis, revealing the association between penetration enhancement effect of essential oils and drug properties (four natures, five flavors, channel tropism) by general linear model. According to the findings: The essential oils which have the good ability to enhance percutaneous absorption were all from acrid Chinese herbal medicine, positive drugs contributed to enhancing the percutaneous absorption of essential oil; Five flavors has little effect on penetration enhancement (P=0.6982), but four natures and channel tropism have signifi