模拟生物膜通道的嵌段共聚物胶束对药物的控制释放.pdfVIP

模拟生物膜通道的嵌段共聚物胶束对药物的控制释放 吕娟，陈熙，史林启 （功能高分子材料教育部重点实验室，南开大学，天津 300071，中国） 摘 要 ：用聚丙烯酸叔丁酯-b-聚乙二醇（PtBA -b-PEG ）和聚丙烯酸叔丁酯-b-聚4-乙烯基吡啶 45 114 （P tBA -b-P4VP ）制备了pH值响应的复合胶束。该胶束在pH=2.5的酸性水溶液中形成以PtBA为核，PEG和P4VP 60 80 为壳的稳定的球形结构。在pH值12时，壳层的P4VP链段变为疏水，塌缩在PtBA的核上，PEG链段继续保持溶解 状态，起到稳定胶束的作用。塌缩的P4VP会在舒展的PEG链段周围形成通道，该通道使PtBA核可以和外界进行 能量或物质交换。将布洛芬负载在PtBA核内进行药物控制释放研究的结果表明，胶束表面的通道可以起到明 显控制布洛芬释放速度的作用，并且药物的释放速度与通道在胶束表面的比例成正比。 关键词：复合胶束；通道；控制释放 Controlled Release for Drug by Micelles of Block Copolymers Mimicking Channels in Biological Membrane LV Juan, CHEN Xi, SHI Linqi (Key Laboratory of Functional Polymer Materials, Ministry of Education, institute of polymer chemistry Nankai University, Tianjin 300071, China) Abstract: Complex micelles with insoluble PtBA block as core and PEG as well as P4VP as shell are prepared by self-assembling of poly(tert-butyl acrylate)-b-poly(ethylene glycol) (PtBA45-b-PEG114) and poly(tert-butyl acrylate)-b-poly(4-vinylpyridine) (PtBA60-b-P4VP80) in water at pH=2.5. The result of dynamic light scattering (DLS) indicates that the complex micelles show larger size than that of the individual micelles comprised of PtBA45-b-PEG114 or PtBA60-b-P4VP80 respectively. Increasing the pH value from 2.5 to 12, the P4VP chains will collapse upon the PtBA core because of their deprotonation, and hydrophilic PEG chains will pass through collapsed P4VP layer from the core and stabilize the whole