课件-国外大学细胞生物学课件-英文9.bioy.pptVIP

Mitochondrial Diseases W2011 D103 Cell Biology – lecture 9 - Suetterlin and MacGregor: all rights reserved. * Diseases result from inherited or spontaneous mutations that affect mitochondrial energy production ? Affect multiple organs but often more pronounced in tissues with high energy requirement (eg heart, brain and muscle) Mutations can occur in mtDNA, in nDNA or in both. Unique considerations for mitochondrial diseases: ? Heteroplasmy: more than one type of mt DNA in an individual (wt and mutant forms) ? variable distribution in different cells or tissues ? Threshold effect (% o