由Logistic多因素回归分析组成的“最优标志物群”结合人工神经网络用于肺癌诊断.pdfVIP

ARTIFICIAL NEURAL NETWORKS (ANN) FOR DIAGNOSIS OF LUNG CANCER : RESULTS OF “OPTIMUM TUMOR MARKERS GROUP” BY LOGISTIC REGRESSION 1 1 1 2 Yongjun Wu , Yiming Wu , Lingbo Qu , Jing Wang 1 College of Public Health, Zhengzhou University, Zhengzhou, China; 450052 2 Department of Respiratory Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China; 450052 ABSTRACT Objectives Lung cancer is popular tumor in the world, it is estimated there are about 1.2 million people ever year. The death for lung cancer accounts for 17.8% among the whole cancer. So in the world, lung cancer is main popular tumor in the 21 century. The early diagnosis is very important to improve survival rates of patients. Tumor markers are substances that can often be detected in higher-than-normal amounts in the blood, urine, or body tissues of some patients with certain types of cancer. It is very useful and convenient for the early diagnosis. However, single marker is not sufficient to diagnose cancer, its sensitivity and specificity are not so good. To improve the diagnostic efficiency of tumor marker, Combined tumor groups are proved to be more powerful, especially used by mathematical evaluation of tumor marker profile employing artificial neural network (ANN) modeling. ANN modeling is very suitable for discrimination of lung cancer. Methods In this paper, CEA 、CA125、NSE 、β2-MG、gastrin、 sIL-6R、sialic acid、pseudouridine 、NO 、Cu、Zn 、Ca ,12 tumor markers were selected. including CEA、CA125、Gastrin and NSE , were detected by RIA 、IRMA 、HPLC a