基于合成基因线路的智能药物.PDFVIP

456 生 物 工 程 学 报 彭曙光 等/基于合成基因线路的智能药物 Chinese Journal of Biotechnology /cjbcn March 25, 2017, 33(3): 456?466 DOI: 10.13345/j.cjb.160425 ?2017 Chin J Biotech, All rights reserved ·应用领域· 彭曙光，谢震 100084 , . . , 2017, 33(3): 456–466. Peng SG, Xie Z. Smart therapeutics based on synthetic gene circuits. Chin J Biotech, 2017, 33(3): 456–466. 摘 要: 合成生物学自诞生以来对生物学领域的研究产生了重要的影响。利用工程学思维与方法，合成生物 学揭开了生命系统许多调控机制，改造并扩展了一系列生物元件，同时带来了广泛的生物医学应用，为疾病诊 断与治疗提供了新的思路。本文综述了适用于哺乳动物细胞或者细菌的合成基因线路并用于疾病诊断与治疗领 域的最新进展，为未来智能药物设计提供新的思路。 : 合成生物学，基因线路，基因治疗，细胞治疗，细菌疗法 Smart therapeutics based on synthetic gene circuits Shuguang Peng, and Zhen Xie MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation , Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing 100084, China Abstract: Synthetic biology has an important impact on biology research since its birth. Applying the thought and methods that reference from electrical engineering, synthetic biology uncovers many regulatory mechanisms of life systems, transforms and expands a series of biological components. Therefore, it brings a wide range of biomedical applications, including providing new ideas for disease diagnosis and treatment. This review describes the latest advances in the field of disease diagnosis and therapy based on mammalian cell or bacterial synthetic gene circuits, and provides new ideas for future smart therapy de