胰腺CT灌注扫描在胰腺癌生物学行为评估中的价值.pdfVIP

胰腺癌近年发病率呈上升趋势，恶性程度 高，预后极差［1］。近年对其病因以及进展机制 的研究虽然取得了一些进展，仍不足以提高其不 《中 》 01 N ON O 01 N 5 7 胰腺CT灌注扫描在胰腺癌生物学行为 评估中的价值 孟凡斌，郭克建，葛春林，宋少伟 中国医科大学附属第一医院普通外科教研室胰腺外科，辽宁 沈阳 110001 ［摘要］ 背景与目的：胰腺癌预后极差。本研究旨在探讨胰腺CT灌注扫描在胰腺癌肿瘤生物学行为评 估中的价值。方法：收集用灌注CT进行诊断的胰腺癌78例，对比正常胰腺及胰腺癌组织血流量(blood flow， BF)、血容量(blood volume，BV)、渗透性(permeability，per)，峰值(peak value，PE)及达峰时间(time to peak，TTP)等参数的差别，并结合临床、病理资料对比分析癌组织各灌注参数水平与反映肿瘤生物学行为指标 间的关系。结果：78例胰腺癌组织的BF值、BV值、per值及PE值均较周围正常胰腺组织显著减低。血清CA199升 高及肿瘤组织CA199表达阳性者BF值明显高于正常者；组织Ki-67阳性者PE值显著高于阴性者；组织CEA阳性者 TTP值显著低于阴性者；高分化胰腺癌组织Per值显著高于中、低分化者。结论：胰腺灌注CT扫描在判断胰腺癌 肿瘤生物学行为方面有应用前景。 ［关键词］ 胰腺癌；灌注CT；生物学行为 DOI: 10.3969/j.issn.1007-3969.2015.05.012 中图分类号：R735.9 文献标志码：A 文章编号：1007-3639(2015)05-0387-05 The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer MENG Fanbin, GUO Kejian, GE Chunlin, SONG Shaowei (Department of Pancreatic Surgery, Department of General Surgery, the First Hospital of China Medical University, Shenyang Liaoning 110001, China) Correspondence to: GUO Kejian E-mail: gkjcmu@ ［Abstract］ Background and purpose: The prognosis of pancreatic cancer is poor. This study aimed to evaluate the value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer. Methods: This study collected 78 cases of pancreatic cancer which diagnosed by the method of pancreatic CT perfusion, and detected the differences of the values of blood flow (BF), blood volume (BV), permeability (per), peak value (PE) and time to peak (TTP) between normal pancreatic tissues and tumor tissues. Combined with clinical and pathological data. Besides, this study evaluated the relationship between perfusion parameters of tumor tissues and tumor size, lymph node metastasis, distant metastasis, preoperative serum CA199 level, Ki-67, p53, CEA, CA199, CD34 expression of tumor tissues. Results: The values of BF, BV, per and PE in pancreatic tumor tissue were significantly lower than those in normal pancreatic tissue. The BF value