9.糖代谢综述.ppt

Note the sigmoidicity for hexokinase IV and the much lower Km for hexokinase I. When blood glucose rises above 5 mM, hexokinase IV activity increases, but hexokinase I is already operating near Vmax at 5 mM glucose and cannot respond to an increase in glucose concentration. Hexokinase I, II, and III have similar kinetic properties. 只存在于肝脏 存在于脑和肾 同工酶Ⅱ主要存在于骨骼肌和心肌，同工酶Ⅲ主要存在于肝脏和肾脏。 Comparison of the kinetic properties of hexokinase IV (glucokinase) and hexokinase I Regulation of hexokinase IV (glucokinase) by sequestration in the nucleus. The protein inhibitor of hexokinase IV is a nuclear binding