2 Antzelevitch英文讲稿(60分).pptVIP

Table 1. Effects of ranolazine (5 μM), dronedarone (10 μM), and their combination on atrial excitability and induction of ACh-mediated persistent AF in the isolated canine coronary-perfused right atria. Action potential duration measured at 90% repolarization (APD90) and effective refractory period (ERP) data presented were obtained from the pectinate muscle region of coronary-perfused atria at a cycle length (CL) of 500 ms (n=5-15). * 0.05 vs. control; ? P 0.05 vs. acetylcholine alone (ACh, 1.0 μM). ? - P 0.05 vs. Ranolazine+ACh and Dronedarone+ACh. Shortest S1-S1 = the shortest CL permitting 1:1 activation. * Wenxin Keli causes a greater abbreviation of action potential duration (APD90) in atria vs. ventricles. Upper panels: superimposed action potentials recorded from atrial and ventricular muscle under control conditions (C) and after addition of 5 g/L Wenxin Keli (W) to the coronary perfusate. Pacing CL = 500 ms. Bottom panels: Plots depict the average APD90 data recorded at pacing CLs of 500 and 300 ms. * - p0.05 vs. control. ** - p0.001 vs. control. * Each of the upper panels shows the earliest premature beat that could be elicited under normal conditions and after Wenxin Keli thus illustrating the end of the effective refractory period. Wenxin therefore prolongs ERP despite its affect to abbreviate the action potential. Wenxin Keli prolongs effective refractory period (ERP) selectively in atria due to induction of post-repolarization refractoriness (PRR) in atria but not in the ventricles. Shown are typical action potentials recorded from atrial and ventricular parts of the coronary-perfused preparation in control and after Wenxin Keli. Each tracing shows a basic beat following by the premature beat with the shortest coupling interval producing an active propagating response, thus depicting the ERP. Summary data: Wenxin Keli prolongs effective refractory period (ERP) selectively in atria due to induction of post-repolarization refractoriness