Absolute measurement of cerebral.pdfVIP

Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy Bertan Hallacoglu Angelo Sassaroli Michael Wysocki Elizabeth Guerrero-Berroa Michal Schnaider Beeri Vahram Haroutunian Merav Shaul Irwin H. Rosenberg Aron M. Troen Sergio Fantini Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy Bertan Hallacoglu,a Angelo Sassaroli,a Michael Wysocki,b Elizabeth Guerrero-Berroa,b Michal Schnaider Beeri,b Vahram Haroutunian,b Merav Shaul,c Irwin H. Rosenberg,c Aron M. Troen,d and Sergio Fantinia aTufts University, Department of Biomedical Engineering, 4 Colby St, Medford, Massachusetts 02155 bMount Sinai School of Medicine, One Gustave L. Levy Place, New York 10029 cTufts University, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts 02111 dHebrew University of Jerusalem, Institute of Biochemistry, Food Science and Nutrition, P.O.Box 12, Rehovot 76100, Israel Abstract We present near-infrared spectroscopy measurement of absolute cerebral hemoglobin concentration and saturation in a large sample of 36 healthy elderly (mean age, 85
6 years) and 19 young adults (mean age, 28
4 years). Non-invasive measurements were obtained on the forehead using a commercially available multi-distance frequency-domain system and analyzed using a diffusion theory model for a semi-infinite, homo- geneous medium with semi-infinite boundary conditions. Our study included repeat measurements, taken five months apart, on 16 elderly volunteers that demonstrate intra-subject reproducibility of the absolute measurements with cross-correlation coefficients of 0.9 for absorption coefficient eμaT, oxy-hemoglobin concentration e?HbO2T, and total hemoglobin concentration e?HbTT, 0.7 for deoxy-hemoglobin concentration e?HbT, 0.8 for hemoglobin oxygen saturation eStO2T, and 0