Breath sensors for lung cancer diagnosis.pdfVIP

Biosensors and Bioelectronics 65 (2015) 121–138Contents lists available at ScienceDirectBiosensors and Bioelectronicshttp://d 0956-56 n Corr E-mjournal homepage: /locate/biosBreath sensors for lung cancer diagnosis Yekbun Adiguzel a,n, Haluk Kulah b,c a Department of Biophysics, School of Medicine, Istanbul Kemerburgaz University, Mahmutbey Dilmenler Caddesi, No. 26, 34217 Bagcilar, Istanbul, Turkey b METU-MEMS Research and Application Center, Middle East Technical University (METU), Ankara, Turkey c METU BioMEMS, Electrical and Electronics Engineering Department, METU, Universiteler Mah., Dumlup?nar Bulv. No. 1, 06800 ?ankaya, Ankara, Turkeya r t i c l e i n f o Article history: Received 26 June 2014 Received in revised form 9 October 2014 Accepted 10 October 2014 Available online 19 October 2014 Keywords: Breath sensor Breath analysis Electronic nose (e-nose) Lung cancer Disease /10.1016/j.bios.2014.10.023 63/ 2014 Elsevier B.V. All rights reserved. esponding author. ail addresses: yekbun.adiguzel@kemerburgaz.ea b s t r a c t The scope of the applications of breath sensors is abundant in disease diagnosis. Lung cancer diagnosis is a well-fitting health-related application of this technology, which is of utmost importance in the health sector, because lung cancer has the highest death rate among all cancer types, and it brings a high yearly global burden. The aim of this review is first to provide a rational basis for the development of breath sensors for lung cancer diagnostics from a historical perspective, which will facilitate the transfer of the idea into the rapidly evolving sensors field. Following examples with diagnostic applications include colorimetric, composite, carbon nanotube, gold nanoparticle-based, and surface acoustic wave sensor arrays. These select sensor applications are widened by the state-of-the-art developments in the sensors field. Coping with sampling sourced artifacts and cancer staging are among the debated topics, along with the other