New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.pdf

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New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.pdf

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New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance

Fitoterapia 96 (2014) 76–80 Contents lists available at ScienceDirect Fitoterapia j ourna l homepage: www.e lsev ie r .com/ locate / f i to teNew cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum HanceDan Liu a, Yan-Wen Liu a, Fu-Qin Guan b, Jing-Yu Liang c,? a Hubei Key Laboratory of Resource Science and Chemistry in Chinese Medicine, Hubei university of Chinese Medicine, Wuhan 430061, China b Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China c Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, Chinaa r t i c l e i n f o? Corresponding author at: Department of Natural China Pharmaceutical University, #24 Tongjiaxiang, China. Tel.: +86 E-mail address: jyliang08@126.com (J.-Y. Liang). /10.1016/j.fitote.2014.04.008 0367-326X/? 2014 Elsevier B.V. All rights reserved.a b s t r a c tArticle history: Received 27 September 2013 Accepted in revised form 11 April 2014 Available online 18 April 2014Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4–6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, IR). The isolated compounds were evaluated for their cytotoxicity against human tumor cell lines HepG2, MCF-7, T98G and B16-F10. Compound 1 showed selective cytotoxicity against cell lines of MCF-7 and T98G, while compound 6 showed significant cytotoxicity to the all tested tumor cell lines with IC50 in the range from 8.46 to 22.68 μmol/L. ? 2014 Elsevier B.V. All rights reserved.Keywords: Alpinia officinarum Hance Diarylheptanoids Cytotoxicity1. Introduction Alpiniae officinarum Rhizoma, named galangal, are the dried rhizomes of Alpinia officinarum Hance (Zingiberaceae). It has been used as a traditional Chinese medicine for relieving stomach ache, treatin