高血压121课件.ppt

Chapter 12;Cardiovascular　diseases;Cardiovascular Drugs;Classification of cardiac drugs;Section 1 Cardiac Agents;充血性心力衰竭(Congestive heart failure，CHF）;Drugs for CHF;The Sorts of Cardiac Agents;1. Cardiac glycosides (强心苷类);;Digoxin in the body ;cardiac glycosides in clinic;Digoxin (地高辛);Digitoxin（洋地黄毒苷） ;;;;1）Chemistry of cardiac glycosides;steroid nucleus ;α,β unsaturated lactone;Sugar moieties;The function of chemical structure;2）The Action Mechanism;Figure of the action mechanism;3) The SAR of cardiac glycosides;Figure of cardiac glycosides and Na+,K+/ATPase action;Methyldigoxin;2. Phosphodiesterase inhibitor, PDEI;The Action Mechanism;Figure of the Action Mechanism;Phosphodiesterase, PDE;Amrinone (氨力农);Pharmacology of Amrinone;;Pharmacology of Milrinone;Enoximone (依洛昔酮）;3. Calcium sensitizers (钙敏化剂);Isomazole (伊索马唑);4. βAdrenergic Agonists;;Denopamine (地诺帕明）;Section 2 Antianginal Drugs;Oxygen supplying;Oxygen requirements ;Antianginal Drugs;Figure of Antianginal Drugs acting;The class of Antianginal Drugs;(1) The Development of NO donor drugs ;Chemistry of nitrates;Nitrates in clinical use today;The chemical natures of nitrates ;Pharmacologic actions of nitrates;The acting duration of nitrates;The onset of organic nitrate action;The duration and onset of nitrates action ;Nitroglycerin（硝酸甘油）;体内作用;Isosorbide Dinitrate;Isosorbide mononitrate;(2) Action mechanism of Nitrates;Action mechanism of Nitrates;(3) Others NO donor drugs ;吗多明（molsidomine）;药理作用;2. Calcium channel blockers ;Action mechanism;Calcium channel blockers ;钙通道;Class of calcium channel blockers ;(1) Selective calcium channel blockers ;A. Dihydropyridines, DHP;;;;;SARs of DHP; B. Aralkylamine derivatives (芳烷基胺类);Varapamil （维拉帕米）;Pharmacologic effects ;C. Benzothiazepine (苯并硫氮卓类)derivatives;;Pharmacologic effects ;;临床用途;二苯基哌嗪类;3. βAdrenergic blockers;βAdrenergic blockers;Section 3 Antiarrhythmic Drugs;心律失常分类;心脏内兴奋的传导;Arrhythmic disease;Configuration of typical ventricular action potential ;心肌细胞