DNA1Lastweekstake-homelessons.pptVIP

DNA1: Last weeks take-home lessons;DNA2: Todays story and goals;DNA 2;Applications of Dynamic Programming;Alignments Scores;Increasingly complex (accurate) searches;Hardness of (multi-) sequence alignment;Separate Training set and Testing sets Need databases of non-redundant sets. Need evaluation criteria (programs) Sensistivity and Specificity (false negatives positives) sensitivity (true_predicted/true) specificity (true_predicted/all_predicted) Where do training sets come from? More expensive experiments: crystallography, genetics, biochemistry ;Pearson WR Protein Sci 1995 Jun;4(6):11