Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispen.pdfVIP

Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL Ramachandran Rashmi, Santhosh Kumar and Devarajan Karunagaran
Cancer Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695 014, India
To whom correspondence should be addressed. Tel: t91 471 2347975; Fax: t91 471 2348096; E-mail: dkarunagaran@ Multiple apoptotic stimuli induce conformational changes in Bax, a proapoptotic protein from the Bcl-2 family and its deficiency is a frequent cause of