脓毒症发病的肠-肝轴机制及下法的调节作用 王伟荣,周仙仕,叶烨.pdf

新中医 年 月第 卷第 期 2017 3 49 3 JOURNAL OF NEW CHINESE MEDICINE March 2017 Vol.49 No.3 ·159 · 脓毒症发病的肠 肝轴机制及下法的调节作用 - 王伟荣，周仙仕，叶烨 广东省中医院急诊科，广东 广州 ?????? ［摘要］ 脓毒症是具有较高发病率及死亡率的急危重症，中医药治疗本病有一定优势。笔者通过理论探索及临床经验总结发 现，脓毒症的发生发展与“肠-肝轴”关系密切；而中医之“下法”及泻下类方药对脓毒症“肠-肝轴”具有显著的调节作用，可 在一定程度上减轻脓毒症常见的肠道屏障损伤及肝功能损害，从而达早期干预及治疗的目的。 ［关键词］ 脓毒症；肠-肝轴；下法 ［中图分类号］ ??????? ［文献标志码］ ? ［文章编号］ ????? ???? （????） ??? ????? ?? ???：????????????????????????????? Mechanism of Intestinal-Liver Axis in Sepsis and Regulatory Effect of Purgation Method ， ， WANG Weirong ZHOU Xianshi YE Ye Abstract：Sepsis is an acute critical disease with high incidence and high mortality. Chinese medicine has certain advantages ， over the treatment of this disease. Through the theoretical exploration and clinical experience summary the authors discover ； that the occurrence and development of sepsis is closely related to the intestine- liver axis and the purgative method as well as ， ， purgatives in Chinese medicine have significant regulatory effect on the intestinal- liver axis of sepsis which to a certain ， extent can reduce the common intestinal barrier damage and liver damage caused