特发性血小板减少性紫癜PRO量表条目的初步筛选.pdfVIP

数字医学基础研究 Basic Research of Digital Medicine 特发性血小板减少性紫癜PRO量表条目的初步筛选 龙远雄① 马利① 何丽云① 闫世艳① 王彬① 王双连① 摘 要 目的：筛选特发性血小板减少性紫癜（ITP）PRO量表条目，形成适合我国ITP患者疗效评价的PRO量表。方法：采 用专家评分法、因子分析法、离散程度法、克朗巴赫系数（Cronbach Alpha）法、相关系数法（包括2种），从条目的重要 性大、敏感性高、独立性强、代表性好、确定性等方面进行筛选。结果：终选量表共54个条目，分为生理、心理和社会3个 领域，其中生理领域包括出血、疼痛与不适、睡眠与休息三个维度，最终保留条目数为36条，心理领域保留12条，社会保 留6条。结论：筛选后的量表离推广运用还有一定差距，还需在其他人群中进行信度和效度检验。 关键词　特发性血小板减少性紫癜 患者报告临床结局（PRO） 条目筛选 Doi:10.3969/j.issn.1673-7571.2015.05.013 [中图分类号] R319;R558 [文献标识码] A Preliminary Screening of PRO Scale Items of Idiopathic Thrombocytopenic Purpura / LONG Yuan-xiong, MA Li, HE Li-yun, et al//China Digital Medicine.-2015 10(5): 42 to 43 Abstract Objective: To screen PRO scale items of idiopathic thrombocytopenic purpura and form the PRO scale suitable for the evaluation of therapeutic efficiency of ITP patients in China. Methods: The expert grading method, factor analysis method, discrete degree method, Cronbach Alpha method and correlation coefficient method (including two methods) are used to screen from the important, high-sensitivity, strong-independence, representative and certain entries. Results: The ultimate scale has a total of 54 items, divided into physiological, psychological and social area. Among them, the physical area includes three dimensions, which are bleeding, pain and discomfort, and sleep and rest. There are a total of 36 final reserved entries, 12 reserved entries in the psychological area and 6 social reserved entries. Conclusion: After the screening the scale still cannot be popularized and applied. We still need to do the reliability and validity test in other groups. Keywords idiopathic thrombocytopenic purpura, patient reported outcome (PRO), entry screening Fund project The 12th Five-Year Plan National Science and Technology Support Subject (No. 2012BAI27B00) Corresponding author Hubei University of Chinsese Medicine, Wuhan 430065, Hubei Pr