胰腺癌血清学标记物在胰腺癌初期诊断中的研究进展.pdfVIP

1 ? 解放军医学院学报 ?? J ?? PLA Med Sch Feb 2015??36(2)http??????jyjxxyxb??paperopen??com 胰腺癌血清学标记物在胰腺癌初期诊断中的研究进展 曾 强，巩燕 解放军总医院健康管理研究院，北京??? ??????????????????????????????????????????????????????????????????????????????????????????????????l?????????? ????????????????????????????????????????????????????????????????????????????????DNA??microRNA?????????? 细胞。联合???种血清学标记物有助于其早期诊断，未来的研究应侧重于筛选胰腺癌高危人群，形成高度敏感性和特异性的 标记物，提高胰腺癌早期诊断水平。 关键词：胰腺癌；血清标记物；早期诊断 ????????????R???文献标志码：?恼卤嗪牛????????????—? DOI??10??39696??issn??2095??5227??2015??02??025 网络出版时间：??—?—? ?：? 网络出版地址：??：／／??甤??畁?／??／???／?．??．???????????．?? Serological markers ? ????? ??? ? early diagnosis ? ????? ??? ?? Qiang??GONGYan ??? ????? and ???? ?????珻??? PLA General ????，??? 100853??China The first ???：?? ???瓻??：?????甤? ????：????? ??? ? a ?? ? malignant tumor which ? ?? difficult ? ???? and ??．????? ? ????? ????? serological markers ? screening the early curable stage ? ????? ??? ?? important ???? ??????．? ????瑃? study ? serological ??? ? ????? ??? ???? the molecular ? ????? cancer-specific ?????，?? mutations??abnormalmethylation ? ?? DNA??microRNAand circulating tumor cells??Combinations? different serological markers Can ????? ? the early diagnosis ? ????? cancer??andfurther ????? ??? focus ? the screening ? ??—?? ??? ?? ????? ??? and the development ? ??? sensitive and ???