复旦研究生《细胞免疫》Peruhype-Magalh-es_et_al-2005-Scandinavian_Journal_of_Immunology.pdfVIP

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复旦研究生《细胞免疫》Peruhype-Magalh-es_et_al-2005-Scandinavian_Journal_of_Immunology.pdf

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doi: 10.1111/j.1365-3083.2005.01686.x ............................................................................................................................................................................................................ Immune Response in Human Visceral Leishmaniasis: Analysis of the Correlation Between Innate Immunity Cytokine Profile and Disease Outcome V. Peruhype-Magalha?es*y, O. A. Martins-Filho*, A. Prataz, L. de A. Silvaz, A. Rabello*, A. Teixeira- Carvalho*§, R. M. Figueiredo{, S. F. Guimara?es-Carvalho**, T. C. A. Ferrariyy R. Correa-Oliveira* Abstract *Centro de Pesquisas Rene′ Rachou, FIOCRUZ, We investigated the cytokine profile of cells of the innate immune response and Belo Horizonte; yInstituto Oswaldo Cruz, its association with active (ACT), asymptomatic (AS) and cured (CUR) human FIOCRUZ, Rio de Janeiro; zFaculdade de visceral leishmaniasis (VL), as well as noninfected (NI) subjects. The frequency Medicina do Tria?ngulo Mineiro, Uberaba; §Universidade Federal de Ouro Preto, Ouro of cytokine-producing cells was determined after short-term in vitro incubation Preto; {Centro Geral de Pediatria, FHEMIG, Belo of whole peripheral blood samples with soluble Leishmania antigen (SLA). Our Horizonte; **Universidade Estadual de Montes data demonstrated a predominant type 2 cytokine profile in NI and ACT. In Claros, Montes Claros; and yyUniversidade NI, we observed an increase of IL-4t neutrophils, IL-10t eosinophils besides a Federal de Minas Gerais, Belo Horizonte, Minas decrease of tumour necrosis factor (TNF)-at eosinophils/monocytes. Yet in Gerais, Brazil ACT, we observed an increase of IL-4t neutrophils and natural killer (NK) t t t Received 24 May 2005; Accepted in revised cells and IL-10 monocyte